The unique entity of nodular lymphocyte-predominant Hodgkin lymphoma: Current approaches to diagnosis and management

Eliza A. Hawkes, Andrew Wotherspoon, David Cunningham

Research output: Contribution to journalReview ArticleResearchpeer-review

14 Citations (Scopus)


Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare disease constituting only 38% of all Hodgkin lymphoma. It has a distinct histological and clinical presentation as well as significantly different natural history compared to the classical form of Hodgkin lymphoma. Presenting most often as early-stage disease, NLPHL is characterized by frequent relapses, but paradoxically an overall good prognosis. The approach to management should therefore reflect this pattern and focus on attaining prolonged remissions, with long-term follow-up paramount. Due to the rarity of the disease, few prospective data exist. Options for treatment include radiotherapy, chemotherapy or combined chemotherapy plus radiotherapy and targeted anti-CD20 antibody therapy, as well as observation in selected patients.

Original languageEnglish
Pages (from-to)354-361
Number of pages8
JournalLeukemia and Lymphoma
Issue number3
Publication statusPublished - Mar 2012
Externally publishedYes


  • Chemotherapy
  • Hodgkin lymphoma
  • Nodular lymphocyte-predominant Hodgkin lymphoma
  • Radiotherapy
  • Rituximab

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