The transfer and decay of maternal antibody against Shigella sonnei in a longitudinal cohort of Vietnamese infants

Corinne N Thompson; Le Thi Phuong Tu; Katherine L. Anders; Nguyen Trong Hieu; Lu Lan Vi; Nguyen Van Vinh Chau; Vu Thuy Duong; Nguyen Ngoc Minh Chau; Tran Thi Hong Chau; Ha Thanh Tuyen; Tran Vu Thieu Nga; Pham Van Minh; Tran Do Hoang Nhu; Le Thi Quynh Nhi; Allan Saul; Laura B. Martin; Audino Podda; Christiane Gerke; Guy Thwaites; Cameron P. Simmons; Stephen Baker

doi:10.1016/j.vaccine.2015.12.047

The transfer and decay of maternal antibody against Shigella sonnei in a longitudinal cohort of Vietnamese infants

Corinne N Thompson, Le Thi Phuong Tu, Katherine L. Anders, Nguyen Trong Hieu, Lu Lan Vi, Nguyen Van Vinh Chau, Vu Thuy Duong, Nguyen Ngoc Minh Chau, Tran Thi Hong Chau, Ha Thanh Tuyen, Tran Vu Thieu Nga, Pham Van Minh, Tran Do Hoang Nhu, Le Thi Quynh Nhi, Allan Saul, Laura B. Martin, Audino Podda, Christiane Gerke, Guy Thwaites, Cameron P. SimmonsStephen Baker

School of Biological Sciences

Research output: Contribution to journal › Article › Research › peer-review

11 Citations (Scopus)

Abstract

Background: Shigella sonnei is an emergent and major diarrheal pathogen for which there is currently no vaccine. We aimed to quantify duration of maternal antibody against S. sonnei and investigate transplacental IgG transfer in a birth cohort in southern Vietnam.

Methods and results: Over 500-paired maternal/infant plasma samples were evaluated for presence of anti-S. sonnei-O IgG and IgM. Longitudinal plasma samples allowed for the estimation of the median half-life of maternal anti-S. sonnei-O IgG, which was 43 days (95% confidence interval: 41-45 days). Additionally, half of infants lacked a detectable titer by 19 weeks of age. Lower cord titers were associated with greater increases in S. sonnei IgG over the first year of life, and the incidence of S. sonnei seroconversion was estimated to be 4/100 infant years. Maternal IgG titer, the ratio of antibody transfer, the season of birth and gestational age were significantly associated with cord titer.

Conclusions: Maternal anti-S. sonnei-O IgG is efficiently transferred across the placenta and anti-S. sonnei-O maternal IgG declines rapidly after birth and is undetectable after 5 months in the majority of children. Preterm neonates and children born to mothers with low IgG titers have lower cord titers and therefore may be at greater risk of seroconversion in infancy.

Original language	English
Pages (from-to)	783-790
Number of pages	8
Journal	Vaccine
Volume	34
Issue number	6
DOIs	https://doi.org/10.1016/j.vaccine.2015.12.047
Publication status	Published - 3 Feb 2016

Keywords

Maternal antibody
Placental transfer
Seroconversion
Shigella

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Thompson, C. N., Tu, L. T. P., Anders, K. L., Hieu, N. T., Vi, L. L., Chau, N. V. V., Duong, V. T., Chau, N. N. M., Chau, T. T. H., Tuyen, H. T., Nga, T. V. T., Minh, P. V., Nhu, T. D. H., Nhi, L. T. Q., Saul, A., Martin, L. B., Podda, A., Gerke, C., Thwaites, G., ... Baker, S. (2016). The transfer and decay of maternal antibody against Shigella sonnei in a longitudinal cohort of Vietnamese infants. Vaccine, 34(6), 783-790. https://doi.org/10.1016/j.vaccine.2015.12.047

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title = "The transfer and decay of maternal antibody against Shigella sonnei in a longitudinal cohort of Vietnamese infants",

abstract = "Background: Shigella sonnei is an emergent and major diarrheal pathogen for which there is currently no vaccine. We aimed to quantify duration of maternal antibody against S. sonnei and investigate transplacental IgG transfer in a birth cohort in southern Vietnam. Methods and results: Over 500-paired maternal/infant plasma samples were evaluated for presence of anti-S. sonnei-O IgG and IgM. Longitudinal plasma samples allowed for the estimation of the median half-life of maternal anti-S. sonnei-O IgG, which was 43 days (95% confidence interval: 41-45 days). Additionally, half of infants lacked a detectable titer by 19 weeks of age. Lower cord titers were associated with greater increases in S. sonnei IgG over the first year of life, and the incidence of S. sonnei seroconversion was estimated to be 4/100 infant years. Maternal IgG titer, the ratio of antibody transfer, the season of birth and gestational age were significantly associated with cord titer. Conclusions: Maternal anti-S. sonnei-O IgG is efficiently transferred across the placenta and anti-S. sonnei-O maternal IgG declines rapidly after birth and is undetectable after 5 months in the majority of children. Preterm neonates and children born to mothers with low IgG titers have lower cord titers and therefore may be at greater risk of seroconversion in infancy.",

keywords = "Maternal antibody, Placental transfer, Seroconversion, Shigella",

author = "Thompson, {Corinne N} and Tu, {Le Thi Phuong} and Anders, {Katherine L.} and Hieu, {Nguyen Trong} and Vi, {Lu Lan} and Chau, {Nguyen Van Vinh} and Duong, {Vu Thuy} and Chau, {Nguyen Ngoc Minh} and Chau, {Tran Thi Hong} and Tuyen, {Ha Thanh} and Nga, {Tran Vu Thieu} and Minh, {Pham Van} and Nhu, {Tran Do Hoang} and Nhi, {Le Thi Quynh} and Allan Saul and Martin, {Laura B.} and Audino Podda and Christiane Gerke and Guy Thwaites and Simmons, {Cameron P.} and Stephen Baker",

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Thompson, CN, Tu, LTP, Anders, KL, Hieu, NT, Vi, LL, Chau, NVV, Duong, VT, Chau, NNM, Chau, TTH, Tuyen, HT, Nga, TVT, Minh, PV, Nhu, TDH, Nhi, LTQ, Saul, A, Martin, LB, Podda, A, Gerke, C, Thwaites, G, Simmons, CP & Baker, S 2016, 'The transfer and decay of maternal antibody against Shigella sonnei in a longitudinal cohort of Vietnamese infants', Vaccine, vol. 34, no. 6, pp. 783-790. https://doi.org/10.1016/j.vaccine.2015.12.047

TY - JOUR

T1 - The transfer and decay of maternal antibody against Shigella sonnei in a longitudinal cohort of Vietnamese infants

AU - Thompson, Corinne N

AU - Tu, Le Thi Phuong

AU - Anders, Katherine L.

AU - Hieu, Nguyen Trong

AU - Vi, Lu Lan

AU - Chau, Nguyen Van Vinh

AU - Duong, Vu Thuy

AU - Chau, Nguyen Ngoc Minh

AU - Chau, Tran Thi Hong

AU - Tuyen, Ha Thanh

AU - Nga, Tran Vu Thieu

AU - Minh, Pham Van

AU - Nhu, Tran Do Hoang

AU - Nhi, Le Thi Quynh

AU - Saul, Allan

AU - Martin, Laura B.

AU - Podda, Audino

AU - Gerke, Christiane

AU - Thwaites, Guy

AU - Simmons, Cameron P.

AU - Baker, Stephen

PY - 2016/2/3

Y1 - 2016/2/3

N2 - Background: Shigella sonnei is an emergent and major diarrheal pathogen for which there is currently no vaccine. We aimed to quantify duration of maternal antibody against S. sonnei and investigate transplacental IgG transfer in a birth cohort in southern Vietnam. Methods and results: Over 500-paired maternal/infant plasma samples were evaluated for presence of anti-S. sonnei-O IgG and IgM. Longitudinal plasma samples allowed for the estimation of the median half-life of maternal anti-S. sonnei-O IgG, which was 43 days (95% confidence interval: 41-45 days). Additionally, half of infants lacked a detectable titer by 19 weeks of age. Lower cord titers were associated with greater increases in S. sonnei IgG over the first year of life, and the incidence of S. sonnei seroconversion was estimated to be 4/100 infant years. Maternal IgG titer, the ratio of antibody transfer, the season of birth and gestational age were significantly associated with cord titer. Conclusions: Maternal anti-S. sonnei-O IgG is efficiently transferred across the placenta and anti-S. sonnei-O maternal IgG declines rapidly after birth and is undetectable after 5 months in the majority of children. Preterm neonates and children born to mothers with low IgG titers have lower cord titers and therefore may be at greater risk of seroconversion in infancy.

AB - Background: Shigella sonnei is an emergent and major diarrheal pathogen for which there is currently no vaccine. We aimed to quantify duration of maternal antibody against S. sonnei and investigate transplacental IgG transfer in a birth cohort in southern Vietnam. Methods and results: Over 500-paired maternal/infant plasma samples were evaluated for presence of anti-S. sonnei-O IgG and IgM. Longitudinal plasma samples allowed for the estimation of the median half-life of maternal anti-S. sonnei-O IgG, which was 43 days (95% confidence interval: 41-45 days). Additionally, half of infants lacked a detectable titer by 19 weeks of age. Lower cord titers were associated with greater increases in S. sonnei IgG over the first year of life, and the incidence of S. sonnei seroconversion was estimated to be 4/100 infant years. Maternal IgG titer, the ratio of antibody transfer, the season of birth and gestational age were significantly associated with cord titer. Conclusions: Maternal anti-S. sonnei-O IgG is efficiently transferred across the placenta and anti-S. sonnei-O maternal IgG declines rapidly after birth and is undetectable after 5 months in the majority of children. Preterm neonates and children born to mothers with low IgG titers have lower cord titers and therefore may be at greater risk of seroconversion in infancy.

KW - Maternal antibody

KW - Placental transfer

KW - Seroconversion

KW - Shigella

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U2 - 10.1016/j.vaccine.2015.12.047

DO - 10.1016/j.vaccine.2015.12.047

M3 - Article

AN - SCOPUS:84958764901

SN - 0264-410X

VL - 34

SP - 783

EP - 790

JO - Vaccine

JF - Vaccine

IS - 6

ER -

The transfer and decay of maternal antibody against Shigella sonnei in a longitudinal cohort of Vietnamese infants

Abstract

Keywords

UN SDGs

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