The transcription factor Pokemon: A new key player in cancer pathogenesis

Takahiro Maeda; Robin M. Hobbs; Pier Paolo Pandolfi

doi:10.1158/0008-5472.CAN-05-1055

The transcription factor Pokemon: A new key player in cancer pathogenesis

Takahiro Maeda, Robin M. Hobbs, Pier Paolo Pandolfi

Research output: Contribution to journal › Review Article › Research › peer-review

93 Citations (Scopus)

Abstract

Learning how critical cell regulatory pathways are controlled may lead to new opportunities for cancer treatment. We recently identified the transcription factor Pokemon as a central regulator of the important tumor suppressor ARF. Pokemon is overexpressed in multiple human cancers and cells lacking Pokemon are refractory to oncogenic transformation. These findings suggest that Pokemon may offer an effective new target for cancer therapeutics.

Original language	English
Pages (from-to)	8575-8578
Number of pages	4
Journal	Cancer Research
Volume	65
Issue number	19
DOIs	https://doi.org/10.1158/0008-5472.CAN-05-1055
Publication status	Published - 1 Oct 2005
Externally published	Yes

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10.1158/0008-5472.CAN-05-1055

Cite this

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AU - Pandolfi, Pier Paolo

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AB - Learning how critical cell regulatory pathways are controlled may lead to new opportunities for cancer treatment. We recently identified the transcription factor Pokemon as a central regulator of the important tumor suppressor ARF. Pokemon is overexpressed in multiple human cancers and cells lacking Pokemon are refractory to oncogenic transformation. These findings suggest that Pokemon may offer an effective new target for cancer therapeutics.

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The transcription factor Pokemon: A new key player in cancer pathogenesis

Abstract

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