The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma

David M. Wong; Lingli Li; Sabine Jurado; Ashleigh King; Rebecca Bamford; Meaghan Wall; Mannu K Walia; Gemma L. Kelly; Carl R Walkley; David M. Tarlinton; Andreas Strasser; Jörg Heierhorst

doi:10.1016/j.celrep.2016.01.012

The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma

David M. Wong, Lingli Li, Sabine Jurado, Ashleigh King, Rebecca Bamford, Meaghan Wall, Mannu K Walia, Gemma L. Kelly, Carl R Walkley, David M. Tarlinton, Andreas Strasser, Jörg Heierhorst

Research output: Contribution to journal › Article › Research › peer-review

28 Citations (Scopus)

Abstract

How MYC promotes the development of cancer remains to be fully understood. Here, we report that the Zn²⁺-finger transcription factor ASCIZ (ATMIN, ZNF822) synergizes with MYC to activate the expression of dynein light chain (DYNLL1, LC8) in the murine Eμ-Myc model of lymphoma. Deletion of Asciz or Dynll1 prevented the abnormal expansion of pre-cells in pre-cancerous Eμ-Myc mice and potentiated the pro-apoptotic activity of MYC in pre-leukemic immature B cells. Constitutive loss of Asciz or Dynll1 delayed lymphoma development in Eμ-Myc mice, and induced deletion of Asciz in established lymphomas extended the survival of tumor-bearing mice. We propose that ASCIZ-dependent upregulation of DYNLL1 levels is essential for the development and expansion of MYC-driven lymphomas by enabling the survival of pre-neoplastic and malignant cells.

Original language	English
Pages (from-to)	1488-1499
Number of pages	12
Journal	Cell Reports
Volume	14
Issue number	6
DOIs	https://doi.org/10.1016/j.celrep.2016.01.012
Publication status	Published - 16 Feb 2016
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1016/j.celrep.2016.01.012

37949182-oaFinal published version, 2.82 MB

Cite this

Wong, D. M., Li, L., Jurado, S., King, A., Bamford, R., Wall, M., Walia, M. K., Kelly, G. L., Walkley, C. R., Tarlinton, D. M., Strasser, A., & Heierhorst, J. (2016). The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma. Cell Reports, 14(6), 1488-1499. https://doi.org/10.1016/j.celrep.2016.01.012

@article{4444ec7a50eb41b899d5753ef59c5f1c,

title = "The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma",

abstract = "How MYC promotes the development of cancer remains to be fully understood. Here, we report that the Zn2+-finger transcription factor ASCIZ (ATMIN, ZNF822) synergizes with MYC to activate the expression of dynein light chain (DYNLL1, LC8) in the murine Eμ-Myc model of lymphoma. Deletion of Asciz or Dynll1 prevented the abnormal expansion of pre-cells in pre-cancerous Eμ-Myc mice and potentiated the pro-apoptotic activity of MYC in pre-leukemic immature B cells. Constitutive loss of Asciz or Dynll1 delayed lymphoma development in Eμ-Myc mice, and induced deletion of Asciz in established lymphomas extended the survival of tumor-bearing mice. We propose that ASCIZ-dependent upregulation of DYNLL1 levels is essential for the development and expansion of MYC-driven lymphomas by enabling the survival of pre-neoplastic and malignant cells.",

author = "Wong, \{David M.\} and Lingli Li and Sabine Jurado and Ashleigh King and Rebecca Bamford and Meaghan Wall and Walia, \{Mannu K\} and Kelly, \{Gemma L.\} and Walkley, \{Carl R\} and Tarlinton, \{David M.\} and Andreas Strasser and J{\"o}rg Heierhorst",

year = "2016",

month = feb,

day = "16",

doi = "10.1016/j.celrep.2016.01.012",

language = "English",

volume = "14",

pages = "1488--1499",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Elsevier",

number = "6",

}

TY - JOUR

T1 - The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma

AU - Wong, David M.

AU - Li, Lingli

AU - Jurado, Sabine

AU - King, Ashleigh

AU - Bamford, Rebecca

AU - Wall, Meaghan

AU - Walia, Mannu K

AU - Kelly, Gemma L.

AU - Walkley, Carl R

AU - Tarlinton, David M.

AU - Strasser, Andreas

AU - Heierhorst, Jörg

PY - 2016/2/16

Y1 - 2016/2/16

N2 - How MYC promotes the development of cancer remains to be fully understood. Here, we report that the Zn2+-finger transcription factor ASCIZ (ATMIN, ZNF822) synergizes with MYC to activate the expression of dynein light chain (DYNLL1, LC8) in the murine Eμ-Myc model of lymphoma. Deletion of Asciz or Dynll1 prevented the abnormal expansion of pre-cells in pre-cancerous Eμ-Myc mice and potentiated the pro-apoptotic activity of MYC in pre-leukemic immature B cells. Constitutive loss of Asciz or Dynll1 delayed lymphoma development in Eμ-Myc mice, and induced deletion of Asciz in established lymphomas extended the survival of tumor-bearing mice. We propose that ASCIZ-dependent upregulation of DYNLL1 levels is essential for the development and expansion of MYC-driven lymphomas by enabling the survival of pre-neoplastic and malignant cells.

AB - How MYC promotes the development of cancer remains to be fully understood. Here, we report that the Zn2+-finger transcription factor ASCIZ (ATMIN, ZNF822) synergizes with MYC to activate the expression of dynein light chain (DYNLL1, LC8) in the murine Eμ-Myc model of lymphoma. Deletion of Asciz or Dynll1 prevented the abnormal expansion of pre-cells in pre-cancerous Eμ-Myc mice and potentiated the pro-apoptotic activity of MYC in pre-leukemic immature B cells. Constitutive loss of Asciz or Dynll1 delayed lymphoma development in Eμ-Myc mice, and induced deletion of Asciz in established lymphomas extended the survival of tumor-bearing mice. We propose that ASCIZ-dependent upregulation of DYNLL1 levels is essential for the development and expansion of MYC-driven lymphomas by enabling the survival of pre-neoplastic and malignant cells.

UR - https://www.scopus.com/pages/publications/84958650086

U2 - 10.1016/j.celrep.2016.01.012

DO - 10.1016/j.celrep.2016.01.012

M3 - Article

C2 - 26832406

AN - SCOPUS:84958650086

SN - 2211-1247

VL - 14

SP - 1488

EP - 1499

JO - Cell Reports

JF - Cell Reports

IS - 6

ER -

The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma

Abstract

UN SDGs

Access to Document

Other files and links

Cite this