The Tom channel in the mitochondrial outer membrane: Alive and kicking

Gabrielle Bains, Trevor Lithgow

Research output: Contribution to journalReview ArticleResearchpeer-review

13 Citations (Scopus)


The targeting of newly-made polypeptides to specific membranes, and the subsequent ability of a membrane to allow only certain polypeptides into its compartment, are essential to maintain the ultrastructure of Eukaryotic cells. Distinct oligomeric protein complexes in each cellular membrane catalyse these translocation processes. A recent report [Hill K et al. Nature 1998;395:516-521 (Ref. 1)] of the reconstitution of the translocation channel from the mitochondrial outer membrane, after producing the major structural component of the channel by recombinant means, promises a system to dissect in molecular detail the exact working of one of these protein translocation machines.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
Issue number1
Publication statusPublished - 1 Jan 1999
Externally publishedYes

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