The time course of drug effects

Hesham Al-Sallami, Venkata Kumar, Cornelia Landersdorfer, Jurgen Bulitta, Stephen Duffull

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Abstract

This review aims to introduce the concepts and principles underpinning the time course of drug effects. Models describing the time course of drug concentrations (pharmacokinetic models) and the ensuing concentration-effect (pharmacodynamics models) as well as the linked time-effect (pharmacokinetic-pharmacodynamic models) are introduced. Different types of drug time-effects models are discussed with examples which aim to explain the time course of onset, duration, and maximal effect that occurs from any given dosing schedule. These drug effects are also described in relation to disease progression models
Original languageEnglish
Pages (from-to)176 - 185
Number of pages10
JournalPharmaceutical Statistics
Volume8
Issue number3
DOIs
Publication statusPublished - 2009

Cite this