The therapeutic potential of a venomous lizard: The use of glucagon-like peptide-1 analogues in the critically ill

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Abstract

Glucagon-like peptide-1 (GLP-1), a principal mediator of the postprandial insulinotropic response in health, has a half-life of minutes. The saliva of the Gila monster contains exendin-4, a structural analogue of human GLP-1, but with a much longer half-life. A synthetic preparation of exendin-4, exenatide, is suitable for human use and effectively lowers glucose in ambulant type 2 diabetic patients. When compared with insulin, exenatide therapy is associated with a reduction in hypoglycaemic episodes and postprandial glycaemic excursions in this group. Accordingly, GLP-1 analogues are appealing therapies for hyperglycaemia in the critically ill patient and warrant further study.

Original languageEnglish
Article number1004
JournalCritical Care
Volume14
Issue number5
DOIs
Publication statusPublished - 21 Oct 2010
Externally publishedYes

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