TY - JOUR
T1 - The therapeutic efficacy of transcranial magnetic stimulation in managing Alzheimer’s disease
T2 - A systemic review and meta-analysis
AU - Wei, Zhenyu
AU - Fu, Jiaqi
AU - Liang, Huazheng
AU - Liu, Mingli
AU - Ye, Xiaofei
AU - Zhong, Ping
N1 - Funding Information:
This study was supported by a First-Class Construction Project of Medical Key Discipline of Yangpu District (YP19ZA08). The funder has no role in the design of the study and collection, analysis, and an Elite Plan of Shidong Hospital in Yangpu District and interpretation of data and in writing the manuscript.
Funding Information:
This study was supported by a First-Class Construction Project of Medical Key Discipline of Yangpu District (YP19ZA08). The funder has no role in the design of the study and collection, analysis, and an Elite Plan of Shidong Hospital in Yangpu District and interpretation of data and in writing the manuscript.
Publisher Copyright:
Copyright © 2022 Wei, Fu, Liang, Liu, Ye and Zhong.
PY - 2022/9/6
Y1 - 2022/9/6
N2 - Background: Repetitive Transcranial Magnetic Stimulation (rTMS) is widely used to treat Alzheimer’s Disease. However, the effect of rTMS is still controversial. The purpose of the present study is to evaluate the effectiveness of rTMS on cognitive performance of AD patients. Methods: We systematically searched relevant literatures in four major databases - PubMed, EMBASE, Web of Science, and the Cochrane Central Register of Controlled Trials [Central] before 28th April 2022. Both randomized controlled trials and cross-section studies that compared the therapeutic effect of rTMS with blank control or sham stimuli were included. Results: A total of 14 studies involving 513 AD patients were finally included for meta-analysis. It was found that rTMS significantly improved global cognitive function (SMD = 0.24, 95%CI, 0.12 to 0.36, P = 0.0001) and daily living ability (IADL: SMD = 0.64, 95%CI, 0.21to 1.08, P = 0.004) in patients with AD, but did not show improvement in language, memory, executive ability, and mood. In further analyses, rTMS at 10 Hz, on a single target with 20 sessions of treatment was shown to produce a positive effect. In addition, improvement in cognitive functions lasted for at least 6 weeks (SMD = 0.67, 95%CI, 0.05 to 1.30,P = 0.04). Conclusion: rTMS can improve the global cognition and daily living ability of AD patients. In addition, attention should be paid to the safety of rTMS in AD patients with seizures. Given the relatively small sample size, our results should be interpreted with caution.
AB - Background: Repetitive Transcranial Magnetic Stimulation (rTMS) is widely used to treat Alzheimer’s Disease. However, the effect of rTMS is still controversial. The purpose of the present study is to evaluate the effectiveness of rTMS on cognitive performance of AD patients. Methods: We systematically searched relevant literatures in four major databases - PubMed, EMBASE, Web of Science, and the Cochrane Central Register of Controlled Trials [Central] before 28th April 2022. Both randomized controlled trials and cross-section studies that compared the therapeutic effect of rTMS with blank control or sham stimuli were included. Results: A total of 14 studies involving 513 AD patients were finally included for meta-analysis. It was found that rTMS significantly improved global cognitive function (SMD = 0.24, 95%CI, 0.12 to 0.36, P = 0.0001) and daily living ability (IADL: SMD = 0.64, 95%CI, 0.21to 1.08, P = 0.004) in patients with AD, but did not show improvement in language, memory, executive ability, and mood. In further analyses, rTMS at 10 Hz, on a single target with 20 sessions of treatment was shown to produce a positive effect. In addition, improvement in cognitive functions lasted for at least 6 weeks (SMD = 0.67, 95%CI, 0.05 to 1.30,P = 0.04). Conclusion: rTMS can improve the global cognition and daily living ability of AD patients. In addition, attention should be paid to the safety of rTMS in AD patients with seizures. Given the relatively small sample size, our results should be interpreted with caution.
KW - activities of daily living
KW - Alzheimer’s disease
KW - cognitive function
KW - repetitive transcranial magnetic stimulation
KW - therapeutic efficacy
UR - http://www.scopus.com/inward/record.url?scp=85138291459&partnerID=8YFLogxK
U2 - 10.3389/fnagi.2022.980998
DO - 10.3389/fnagi.2022.980998
M3 - Review Article
C2 - 36147701
AN - SCOPUS:85138291459
SN - 1663-4365
VL - 14
JO - Frontiers in Aging Neuroscience
JF - Frontiers in Aging Neuroscience
M1 - 980998
ER -