The Temporal Profile of Retinal Cell Genesis in the Marmoset Monkey

A Hendrickson, D Possin, W. C. Kwan, J. Huang, J. A. Bourne

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2 Citations (Scopus)

Abstract

The New World marmoset monkey (Callithrix jacchus) has a relatively short gestational period compared with other primates but possesses a retina at a similar stage of maturation by birth. Previous studies have highlighted that the complex fovea of the marmoset undergoes a more rapid postnatal development in comparison to the Macaca monkey, reaching a mature stage earlier than these species. In this current study, we examined the prenatal proliferation profile of cells in the entire retina employing the thymidine analog bromodeoxyuridine, and also determined their phenotype by double-label immunocytochemistry using type-specific markers. Akin to other primate species, we demonstrate a centroperipheral gradient in the emergence of both neurons and Muller glia with cones, ganglion cells and horizontal cells generated first in the fovea at Fd70-74 and with the last generated at the retinal edge at Fd115. Rods, bipolar cells, amacrine cells, displaced amacrine cells, and Muller glia were generated between Fd76 and Fd135 along the same gradient. Similar to foveal development, marmoset neuronal generation was rapid, only taking 51 of gestation while in Macaca this takes 81 . This article is protected by copyright. All rights reserved.
Original languageEnglish
Pages (from-to)1193-1207
Number of pages15
JournalThe Journal of Comparative Neurology
Volume524
Issue number6
DOIs
Publication statusPublished - 2016

Keywords

  • Callithrix jacchus
  • eye
  • glia
  • neuron
  • Thymidine analogs

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