The TAM, a Translocation and Assembly Module for protein assembly and potential conduit for phospholipid transfer

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The assembly of β-barrel proteins into the bacterial outer membrane is an essential process enabling the colonization of new environmental niches. The TAM was discovered as a module of the β-barrel protein assembly machinery; it is a heterodimeric complex composed of an outer membrane protein (TamA) bound to an inner membrane protein (TamB). The TAM spans the periplasm, providing a scaffold through the peptidoglycan layer and catalyzing the translocation and assembly of β-barrel proteins into the outer membrane. Recently, studies on another membrane protein (YhdP) have suggested that TamB might play a role in phospholipid transport to the outer membrane. Here we review and re-evaluate the literature covering the experimental studies on the TAM over the past decade, to reconcile what appear to be conflicting claims on the function of the TAM.

Original languageEnglish
Pages (from-to)1711-1720
Number of pages10
JournalEMBO Reports
Publication statusPublished - Apr 2024


  • BAM Complex
  • Beta-barrel Proteins
  • Lipid Transport
  • Outer Membrane Biogenesis
  • TamB

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