The TACI receptor regulates T-cell-independent marginal zone B cell responses through innate activation-induced cell death

William Arthur Figgett, Kirsten Fairfax, Fabien Vincent, Melanie Le Page, Indzi Katik, Devy Deliyanti, Pin Shie Quah, Pali Verma, Raelene Joy Grumont, Steven Demetrious Gerondakis, Paul John Hertzog, Lorraine A O'Reilly, Andreas Strasser, Fabienne Mackay-Fisson

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30 Citations (Scopus)

Abstract

Activation-induced cell death (AICD) plays a critical role in immune homeostasis and tolerance. In T-cell-dependent humoral responses, AICD of B cells is initiated by Fas ligand (FasL) on T cells, stimulating the Fas receptor on B cells. In contrast, T-cell-independent B cell responses involve innate-type B lymphocytes, such as marginal zone (MZ) B cells, and little is known about the mechanisms that control AICD during innate B cell responses to Toll-like receptor (TLR) activation. Here, we show that MZ B cells undergo AICD in response to TLR4 activation in vivo. The transmembrane activator, calcium modulator, and cyclophilin ligand interactor (TACI) receptor and TLR4 cooperate to upregulate expression of both FasL and Fas on MZ B cells and also to repress inhibitors of Fas-induced apoptosis signaling. These findings demonstrate an unappreciated role for TACI and its ligands in the regulation of AICD during T-cell-independent B cell responses.
Original languageEnglish
Pages (from-to)573 - 583
Number of pages11
JournalImmunity
Volume39
Issue number3
DOIs
Publication statusPublished - 2013

Cite this

Figgett, William Arthur ; Fairfax, Kirsten ; Vincent, Fabien ; Le Page, Melanie ; Katik, Indzi ; Deliyanti, Devy ; Quah, Pin Shie ; Verma, Pali ; Grumont, Raelene Joy ; Gerondakis, Steven Demetrious ; Hertzog, Paul John ; O'Reilly, Lorraine A ; Strasser, Andreas ; Mackay-Fisson, Fabienne. / The TACI receptor regulates T-cell-independent marginal zone B cell responses through innate activation-induced cell death. In: Immunity. 2013 ; Vol. 39, No. 3. pp. 573 - 583.
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title = "The TACI receptor regulates T-cell-independent marginal zone B cell responses through innate activation-induced cell death",
abstract = "Activation-induced cell death (AICD) plays a critical role in immune homeostasis and tolerance. In T-cell-dependent humoral responses, AICD of B cells is initiated by Fas ligand (FasL) on T cells, stimulating the Fas receptor on B cells. In contrast, T-cell-independent B cell responses involve innate-type B lymphocytes, such as marginal zone (MZ) B cells, and little is known about the mechanisms that control AICD during innate B cell responses to Toll-like receptor (TLR) activation. Here, we show that MZ B cells undergo AICD in response to TLR4 activation in vivo. The transmembrane activator, calcium modulator, and cyclophilin ligand interactor (TACI) receptor and TLR4 cooperate to upregulate expression of both FasL and Fas on MZ B cells and also to repress inhibitors of Fas-induced apoptosis signaling. These findings demonstrate an unappreciated role for TACI and its ligands in the regulation of AICD during T-cell-independent B cell responses.",
author = "Figgett, {William Arthur} and Kirsten Fairfax and Fabien Vincent and {Le Page}, Melanie and Indzi Katik and Devy Deliyanti and Quah, {Pin Shie} and Pali Verma and Grumont, {Raelene Joy} and Gerondakis, {Steven Demetrious} and Hertzog, {Paul John} and O'Reilly, {Lorraine A} and Andreas Strasser and Fabienne Mackay-Fisson",
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The TACI receptor regulates T-cell-independent marginal zone B cell responses through innate activation-induced cell death. / Figgett, William Arthur; Fairfax, Kirsten; Vincent, Fabien; Le Page, Melanie; Katik, Indzi; Deliyanti, Devy; Quah, Pin Shie; Verma, Pali; Grumont, Raelene Joy; Gerondakis, Steven Demetrious; Hertzog, Paul John; O'Reilly, Lorraine A; Strasser, Andreas; Mackay-Fisson, Fabienne.

In: Immunity, Vol. 39, No. 3, 2013, p. 573 - 583.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - The TACI receptor regulates T-cell-independent marginal zone B cell responses through innate activation-induced cell death

AU - Figgett, William Arthur

AU - Fairfax, Kirsten

AU - Vincent, Fabien

AU - Le Page, Melanie

AU - Katik, Indzi

AU - Deliyanti, Devy

AU - Quah, Pin Shie

AU - Verma, Pali

AU - Grumont, Raelene Joy

AU - Gerondakis, Steven Demetrious

AU - Hertzog, Paul John

AU - O'Reilly, Lorraine A

AU - Strasser, Andreas

AU - Mackay-Fisson, Fabienne

PY - 2013

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N2 - Activation-induced cell death (AICD) plays a critical role in immune homeostasis and tolerance. In T-cell-dependent humoral responses, AICD of B cells is initiated by Fas ligand (FasL) on T cells, stimulating the Fas receptor on B cells. In contrast, T-cell-independent B cell responses involve innate-type B lymphocytes, such as marginal zone (MZ) B cells, and little is known about the mechanisms that control AICD during innate B cell responses to Toll-like receptor (TLR) activation. Here, we show that MZ B cells undergo AICD in response to TLR4 activation in vivo. The transmembrane activator, calcium modulator, and cyclophilin ligand interactor (TACI) receptor and TLR4 cooperate to upregulate expression of both FasL and Fas on MZ B cells and also to repress inhibitors of Fas-induced apoptosis signaling. These findings demonstrate an unappreciated role for TACI and its ligands in the regulation of AICD during T-cell-independent B cell responses.

AB - Activation-induced cell death (AICD) plays a critical role in immune homeostasis and tolerance. In T-cell-dependent humoral responses, AICD of B cells is initiated by Fas ligand (FasL) on T cells, stimulating the Fas receptor on B cells. In contrast, T-cell-independent B cell responses involve innate-type B lymphocytes, such as marginal zone (MZ) B cells, and little is known about the mechanisms that control AICD during innate B cell responses to Toll-like receptor (TLR) activation. Here, we show that MZ B cells undergo AICD in response to TLR4 activation in vivo. The transmembrane activator, calcium modulator, and cyclophilin ligand interactor (TACI) receptor and TLR4 cooperate to upregulate expression of both FasL and Fas on MZ B cells and also to repress inhibitors of Fas-induced apoptosis signaling. These findings demonstrate an unappreciated role for TACI and its ligands in the regulation of AICD during T-cell-independent B cell responses.

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