Both racemic exo and endo isomers of N6-(5,6-epoxynorborn-2-yl)adenosine have been synthesised and shown to be potent agonists for the A1adenosine receptor. Crucial to the preparation of these compounds is the synthesis of exo and endo norbornenylamines which are accessed through an optimised Curtius rearrangement.
Scammells, P. J., Baker, S. P., Baker, S. P., Bellardinelli, L., Bellardinelli, L., Olsson, R. A., Russell, R. A., & Wright, D. M. J. (1996). The synthesis of the novel adenosine agonists, exo- and endo- N6-(5,6-epoxynorborn-2-yl)adenosine. Tetrahedron, 52(13), 4735-4744. https://doi.org/10.1016/0040-4020(96)00144-5