The synthesis of the novel adenosine agonists, exo- and endo- N6-(5,6-epoxynorborn-2-yl)adenosine

Peter J. Scammells, Stephen P. Baker, Stephen P. Baker, Luiz Bellardinelli, Luiz Bellardinelli, Ray A. Olsson, Richard A. Russell, Denis M.J. Wright

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Abstract

Both racemic exo and endo isomers of N6-(5,6-epoxynorborn-2-yl)adenosine have been synthesised and shown to be potent agonists for the A1adenosine receptor. Crucial to the preparation of these compounds is the synthesis of exo and endo norbornenylamines which are accessed through an optimised Curtius rearrangement.
Original languageEnglish
Pages (from-to)4735-4744
Number of pages10
JournalTetrahedron
Volume52
Issue number13
DOIs
Publication statusPublished - 1 Jan 1996

Cite this

Scammells, P. J., Baker, S. P., Baker, S. P., Bellardinelli, L., Bellardinelli, L., Olsson, R. A., Russell, R. A., & Wright, D. M. J. (1996). The synthesis of the novel adenosine agonists, exo- and endo- N6-(5,6-epoxynorborn-2-yl)adenosine. Tetrahedron, 52(13), 4735-4744. https://doi.org/10.1016/0040-4020(96)00144-5