The synthesis and tubulin binding activity of thiophene-based analogues of combretastatin A-4

Bernard L. Flynn, Guy P. Flynn, Ernest Hamel, M. Katherine Jung

Research output: Contribution to journalArticleResearchpeer-review

124 Citations (Scopus)

Abstract

A number of analogues of combretastatin A-4 (1), containing a thiophene ring interposed between the two phenyl groups, have been prepared. The synthesis of these compounds employed a combination of palladium-mediated coupling and iodocyclization techniques. The thiophene compounds 11, 14, 18, and 19 also represent non-benzofused analogues of some recently described tubulin binding benzo[b]thiophenes 3-5. The most active thiophene compounds identified in this study were 11, 14, and 18. Overall they are less active than 1 but exhibit comparable activity to the most active of the benzo[b]thiophenes 3-5. A structure-activity relationship of these compounds is considered.

Original languageEnglish
Pages (from-to)2341-2343
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number17
DOIs
Publication statusPublished - 3 Sep 2001
Externally publishedYes

Cite this