The Study of Mental and Resistance Training (SMART) study - resistance training and/or cognitive training in mild cognitive impairment: a randomized, double-blind, double-sham controlled trial

Maria A Fiatarone Singh, Nicola Gates, Nidhi Saigal, Guy C Wilson, Jacinda Meiklejohn, Henry Brodaty, Wei Wen, Nalin A Singh, Bernhard T Baune, Chao Suo, Michael K Baker, Nasim Foroughi, Yi Wang, Perminder Singh Sachdev, Michael J Valenzuela

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252 Citations (Scopus)


Background: Mild cognitive impairment (MCI) increases dementia risk with no pharmacologic treatment available. Methods: The Study of Mental and Resistance Training was a randomized, double-blind, double-sham controlled trial of adults with MCI. Participants were randomized to 2 supervised interventions: active or sham physical training (high intensity progressive resistance training vs seated calisthenics) plus active or sham cognitive training (computerized, multidomain cognitive training vs watching videos/quizzes), 2-3days/week for 6months with 18-month follow-up. Primary outcomes were global cognitive function (Alzheimer s Disease Assessment Scale-cognitive subscale; ADAS-Cog) and functional independence (Bayer Activities of Daily Living). Secondary outcomes included executive function, memory, and speed/attention tests, and cognitive domain scores. Results: One hundred adults with MCI [70.1 (6.7) years; 68 women] were enrolled and analyzed. Resistance training significantly improved the primary outcome ADAS-Cog; [relative effect size (95 confidence interval)-0.33 (-0.73, 0.06); P
Original languageEnglish
Pages (from-to)873 - 880
Number of pages8
Issue number12
Publication statusPublished - 2014

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