TY - JOUR
T1 - The Study of Mental and Resistance Training (SMART) study - resistance training and/or cognitive training in mild cognitive impairment: a randomized, double-blind, double-sham controlled trial
AU - Fiatarone Singh, Maria A
AU - Gates, Nicola
AU - Saigal, Nidhi
AU - Wilson, Guy C
AU - Meiklejohn, Jacinda
AU - Brodaty, Henry
AU - Wen, Wei
AU - Singh, Nalin A
AU - Baune, Bernhard T
AU - Suo, Chao
AU - Baker, Michael K
AU - Foroughi, Nasim
AU - Wang, Yi
AU - Sachdev, Perminder Singh
AU - Valenzuela, Michael J
PY - 2014
Y1 - 2014
N2 - Background: Mild cognitive impairment (MCI) increases dementia risk with no pharmacologic treatment available. Methods: The Study of Mental and Resistance Training was a randomized, double-blind, double-sham controlled trial of adults with MCI. Participants were randomized to 2 supervised interventions: active or sham physical training (high intensity progressive resistance training vs seated calisthenics) plus active or sham cognitive training (computerized, multidomain cognitive training vs watching videos/quizzes), 2-3days/week for 6months with 18-month follow-up. Primary outcomes were global cognitive function (Alzheimer s Disease Assessment Scale-cognitive subscale; ADAS-Cog) and functional independence (Bayer Activities of Daily Living). Secondary outcomes included executive function, memory, and speed/attention tests, and cognitive domain scores. Results: One hundred adults with MCI [70.1 (6.7) years; 68 women] were enrolled and analyzed. Resistance training significantly improved the primary outcome ADAS-Cog; [relative effect size (95 confidence interval)-0.33 (-0.73, 0.06); P
AB - Background: Mild cognitive impairment (MCI) increases dementia risk with no pharmacologic treatment available. Methods: The Study of Mental and Resistance Training was a randomized, double-blind, double-sham controlled trial of adults with MCI. Participants were randomized to 2 supervised interventions: active or sham physical training (high intensity progressive resistance training vs seated calisthenics) plus active or sham cognitive training (computerized, multidomain cognitive training vs watching videos/quizzes), 2-3days/week for 6months with 18-month follow-up. Primary outcomes were global cognitive function (Alzheimer s Disease Assessment Scale-cognitive subscale; ADAS-Cog) and functional independence (Bayer Activities of Daily Living). Secondary outcomes included executive function, memory, and speed/attention tests, and cognitive domain scores. Results: One hundred adults with MCI [70.1 (6.7) years; 68 women] were enrolled and analyzed. Resistance training significantly improved the primary outcome ADAS-Cog; [relative effect size (95 confidence interval)-0.33 (-0.73, 0.06); P
UR - http://www.jamda.com/article/S1525-8610(14)00612-4/pdf
U2 - 10.1016/j.jamda.2014.09.010
DO - 10.1016/j.jamda.2014.09.010
M3 - Article
VL - 15
SP - 873
EP - 880
JO - Journal of the American Medical Directors Association
JF - Journal of the American Medical Directors Association
SN - 1525-8610
IS - 12
ER -