The structure and function of G-protein-coupled receptors

Daniel M. Rosenbaum, Søren G F Rasmussen, Brian K. Kobilka

Research output: Contribution to journalReview ArticleResearchpeer-review

1294 Citations (Scopus)

Abstract

G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to hormones, neurotransmitters and environmental stimulants, and so have great potential as therapeutic targets for a broad spectrum of diseases. They are also fascinating molecules from the perspective of membrane-protein structure and biology. Great progress has been made over the past three decades in understanding diverse GPCRs, from pharmacology to functional characterization in vivo. Recent high-resolution structural studies have provided insights into the molecular mechanisms of GPCR activation and constitutive activity.

Original languageEnglish
Pages (from-to)356-363
Number of pages8
JournalNature
Volume459
Issue number7245
DOIs
Publication statusPublished - 21 May 2009
Externally publishedYes

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