The structure and expression of the genes for T-kininogen in the rat

T. J. Cole, G. Schreiber

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Abstract

T-kininogen plays an important role in the acute phase response to trauma in the rat as a possible source of kinins and as a cysteine proteinase inhibitor. Two T-kininogens are expressed by rat liver from two separate genes. T-kininogen expression in liver during the acute phase response is regulated at the level of transcription. The similarity in T- and K-kininogen gene structure suggests divergent evolution from a common gene ancestor.

Original languageEnglish
Pages (from-to)292-299
Number of pages8
JournalAgents and Actions
Volume38
Issue numberSUPPL. I
Publication statusPublished - 1992
Externally publishedYes

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