The structural bases of direct T-cell allorecognition: Implications for T-cell-mediated transplant rejection

Stephanie Gras, Lars Kjer-Nielsen, Zhenjun Chen, Jamie Rossjohn, James McCluskey

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Abstract

alphabeta T-cell receptors (TCRs), which can engage a broad array of foreign peptide-laden major histocompatibility complex (pMHC) landscapes, have an essential role in protective immunity. TCRs are selected by pMHC molecules in the thymus and in the periphery, and so are restricted to recognizing self -major histocompatibility complex (MHC) molecules. Accordingly, T cells are inherently cross-reactive, and although the versatility and specificity of this MHC-restricted response are the hallmarks of adaptive immunity, unwanted TCR interactions, such as those observed in T-cell alloreactivity, often occur. Recent data have shown that direct T-cell alloreactivity can arise from peptide-dependent molecular mimicry, as well as distinct pMHC-binding modes. Here we review recent advances in the field, focusing on structural data pertaining to alloreactivity, and discuss the implications for T-cell-mediated transplant rejection.
Original languageEnglish
Pages (from-to)388 - 395
Number of pages8
JournalImmunology and Cell Biology
Volume89
Issue number3
DOIs
Publication statusPublished - 2011

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