The start-ups taking nanoneedles into the clinic

Roey Elnathan, Andy Tay, Nicolas H. Voelcker, Ciro Chiappini

Research output: Contribution to journalComment / DebateOtherpeer-review

16 Citations (Scopus)


Nanotechnology has matured to the point where it provides exquisite solutions to key challenges across medicine and biology, as seen in the success of delivery nanovectors for COVID-19vaccines1. Among these nanotechnologies, nanoneedles — vertical arrays of high aspect-ratio nanomaterials — have emerged as a simple, controllable and powerful tool to efficiently access cells with minimalperturbation2. Nanoneedles are rapidly emerging as competitive solutions forsensing3, and offer a path to transforming gene and cell therapies4,5. Realizing the transformative potential of nanoneedles is a work in progress. In this Comment, we discuss the burgeoning advances and strong commercial activities of nanoneedle technology through the eyes of leading researchers, entrepreneurs and venture capitalists — all of them major players in the evolution of a viable nanoneedle technology for sensing and clinical use.
Original languageEnglish
Pages (from-to)807-811
Number of pages5
JournalNature Nanotechnology
Issue number8
Publication statusPublished - Aug 2022

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