The stability and complexity of antibody responses to the major surface antigen of Plasmodium falciparum are associated with age in a malaria endemic area

Alyssa E Barry, Angela Trieu, Freya J I Fowkes, Jozelyn Pablo, Mina Kalantari-Dehaghi, Algis Jasinskas, Xiaolin Tan, Matthew A Kayala, Livingstone Tavul, Peter Siba, Karen P Day, Pierre Baldi, Philip L Felgner, Denise L Doolan

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Abstract

Individuals that are exposed to malaria eventually develop immunity to the disease with one possible mechanism being the gradual acquisition of antibodies to the range of parasite variant surface antigens in their local area. Major antibody targets include the large and highly polymorphic Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) family of proteins. Here, we use a protein microarray containing 123 recombinant PfEMP1-DBLI? domains (VAR) from Papua New Guinea to seroprofile 38 nonimmune children (
Original languageEnglish
Pages (from-to)1 - 10
Number of pages10
JournalMolecular & Cellular Proteomics
Volume10
Issue numberArt. No: M111.008326
DOIs
Publication statusPublished - 2011

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