The stability and complexity of antibody responses to the major surface antigen of Plasmodium falciparum are associated with age in a malaria endemic area

Alyssa E Barry; Angela Trieu; Freya J I Fowkes; Jozelyn Pablo; Mina Kalantari-Dehaghi; Algis Jasinskas; Xiaolin Tan; Matthew A Kayala; Livingstone Tavul; Peter Siba; Karen P Day; Pierre Baldi; Philip L Felgner; Denise L Doolan

doi:10.1074/mcp.M111.008326

The stability and complexity of antibody responses to the major surface antigen of Plasmodium falciparum are associated with age in a malaria endemic area

Alyssa E Barry, Angela Trieu, Freya J I Fowkes, Jozelyn Pablo, Mina Kalantari-Dehaghi, Algis Jasinskas, Xiaolin Tan, Matthew A Kayala, Livingstone Tavul, Peter Siba, Karen P Day, Pierre Baldi, Philip L Felgner, Denise L Doolan

Medicine Alfred Hospital

Research output: Contribution to journal › Article › Research › peer-review

63 Citations (Scopus)

Abstract

Individuals that are exposed to malaria eventually develop immunity to the disease with one possible mechanism being the gradual acquisition of antibodies to the range of parasite variant surface antigens in their local area. Major antibody targets include the large and highly polymorphic Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) family of proteins. Here, we use a protein microarray containing 123 recombinant PfEMP1-DBLI? domains (VAR) from Papua New Guinea to seroprofile 38 nonimmune children (

Original language	English
Pages (from-to)	1-10
Number of pages	10
Journal	Molecular & Cellular Proteomics
Volume	10
Issue number	11
DOIs	https://doi.org/10.1074/mcp.M111.008326
Publication status	Published - 2011

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10.1074/mcp.M111.008326

Cite this

Barry, A. E., Trieu, A., Fowkes, F. J. I., Pablo, J., Kalantari-Dehaghi, M., Jasinskas, A., Tan, X., Kayala, M. A., Tavul, L., Siba, P., Day, K. P., Baldi, P., Felgner, P. L., & Doolan, D. L. (2011). The stability and complexity of antibody responses to the major surface antigen of Plasmodium falciparum are associated with age in a malaria endemic area. Molecular & Cellular Proteomics, 10(11), 1-10. https://doi.org/10.1074/mcp.M111.008326

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abstract = "Individuals that are exposed to malaria eventually develop immunity to the disease with one possible mechanism being the gradual acquisition of antibodies to the range of parasite variant surface antigens in their local area. Major antibody targets include the large and highly polymorphic Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) family of proteins. Here, we use a protein microarray containing 123 recombinant PfEMP1-DBLI? domains (VAR) from Papua New Guinea to seroprofile 38 nonimmune children (",

author = "Barry, {Alyssa E} and Angela Trieu and Fowkes, {Freya J I} and Jozelyn Pablo and Mina Kalantari-Dehaghi and Algis Jasinskas and Xiaolin Tan and Kayala, {Matthew A} and Livingstone Tavul and Peter Siba and Day, {Karen P} and Pierre Baldi and Felgner, {Philip L} and Doolan, {Denise L}",

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Barry, AE, Trieu, A, Fowkes, FJI, Pablo, J, Kalantari-Dehaghi, M, Jasinskas, A, Tan, X, Kayala, MA, Tavul, L, Siba, P, Day, KP, Baldi, P, Felgner, PL & Doolan, DL 2011, 'The stability and complexity of antibody responses to the major surface antigen of Plasmodium falciparum are associated with age in a malaria endemic area', Molecular & Cellular Proteomics, vol. 10, no. 11, pp. 1-10. https://doi.org/10.1074/mcp.M111.008326

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AU - Barry, Alyssa E

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AU - Pablo, Jozelyn

AU - Kalantari-Dehaghi, Mina

AU - Jasinskas, Algis

AU - Tan, Xiaolin

AU - Kayala, Matthew A

AU - Tavul, Livingstone

AU - Siba, Peter

AU - Day, Karen P

AU - Baldi, Pierre

AU - Felgner, Philip L

AU - Doolan, Denise L

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AB - Individuals that are exposed to malaria eventually develop immunity to the disease with one possible mechanism being the gradual acquisition of antibodies to the range of parasite variant surface antigens in their local area. Major antibody targets include the large and highly polymorphic Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) family of proteins. Here, we use a protein microarray containing 123 recombinant PfEMP1-DBLI? domains (VAR) from Papua New Guinea to seroprofile 38 nonimmune children (

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