The SPICE III study protocol and analysis plan: a randomised trial of early goal-directed sedation compared with standard care in mechanically ventilated patients (Protocol)

Yahya Shehabi, Andrew B. Forbes, Yaseen Arabi, Frances Bass, Rinaldo Bellomo, Suhaini Kadiman, Belinda D. Howe, Colin McArthur, Michael C. Reade, Ian Seppelt, Jukka Takala, Steve Webb, Matthew P. Wise, for the SPICE III study investigators, the Australian and New Zealand Intensive Care Society Clinical Trials Group and the Australian and New Zealand Intensive Care Research Centre

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