TY - JOUR
T1 - The SOCS box
T2 - A tale of destruction and degradation
AU - Kile, Benjamin T.
AU - Schulman, Brenda A.
AU - Alexander, Warren S.
AU - Nicola, Nicos A.
AU - Martin, Helene M.E.
AU - Hilton, Douglas J.
PY - 2002/5/1
Y1 - 2002/5/1
N2 - Although initially identified in the suppressor of cytokine signaling (SOCS) family of proteins, the C-terminal SOCS box has now been identified in more than 40 proteins in nine different families. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS proteins regulate protein turnover by targeting proteins for polyubiquitination and, therefore, for proteasome-mediated degradation.
AB - Although initially identified in the suppressor of cytokine signaling (SOCS) family of proteins, the C-terminal SOCS box has now been identified in more than 40 proteins in nine different families. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS proteins regulate protein turnover by targeting proteins for polyubiquitination and, therefore, for proteasome-mediated degradation.
UR - http://www.scopus.com/inward/record.url?scp=0036558025&partnerID=8YFLogxK
U2 - 10.1016/S0968-0004(02)02085-6
DO - 10.1016/S0968-0004(02)02085-6
M3 - Review Article
C2 - 12076535
AN - SCOPUS:0036558025
VL - 27
SP - 235
EP - 241
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
SN - 0968-0004
IS - 5
ER -