The SOCS box: A tale of destruction and degradation

Benjamin T. Kile, Brenda A. Schulman, Warren S. Alexander, Nicos A. Nicola, Helene M.E. Martin, Douglas J. Hilton

Research output: Contribution to journalReview ArticleResearchpeer-review

374 Citations (Scopus)


Although initially identified in the suppressor of cytokine signaling (SOCS) family of proteins, the C-terminal SOCS box has now been identified in more than 40 proteins in nine different families. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS proteins regulate protein turnover by targeting proteins for polyubiquitination and, therefore, for proteasome-mediated degradation.

Original languageEnglish
Pages (from-to)235-241
Number of pages7
JournalTrends in Biochemical Sciences
Issue number5
Publication statusPublished - 1 May 2002
Externally publishedYes

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