The SOCS box

A tale of destruction and degradation

Benjamin T. Kile, Brenda A. Schulman, Warren S. Alexander, Nicos A. Nicola, Helene M.E. Martin, Douglas J. Hilton

Research output: Contribution to journalReview ArticleResearchpeer-review

325 Citations (Scopus)

Abstract

Although initially identified in the suppressor of cytokine signaling (SOCS) family of proteins, the C-terminal SOCS box has now been identified in more than 40 proteins in nine different families. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS proteins regulate protein turnover by targeting proteins for polyubiquitination and, therefore, for proteasome-mediated degradation.

Original languageEnglish
Pages (from-to)235-241
Number of pages7
JournalTrends in Biochemical Sciences
Volume27
Issue number5
DOIs
Publication statusPublished - 1 May 2002
Externally publishedYes

Cite this

Kile, B. T., Schulman, B. A., Alexander, W. S., Nicola, N. A., Martin, H. M. E., & Hilton, D. J. (2002). The SOCS box: A tale of destruction and degradation. Trends in Biochemical Sciences, 27(5), 235-241. https://doi.org/10.1016/S0968-0004(02)02085-6
Kile, Benjamin T. ; Schulman, Brenda A. ; Alexander, Warren S. ; Nicola, Nicos A. ; Martin, Helene M.E. ; Hilton, Douglas J. / The SOCS box : A tale of destruction and degradation. In: Trends in Biochemical Sciences. 2002 ; Vol. 27, No. 5. pp. 235-241.
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Kile, BT, Schulman, BA, Alexander, WS, Nicola, NA, Martin, HME & Hilton, DJ 2002, 'The SOCS box: A tale of destruction and degradation', Trends in Biochemical Sciences, vol. 27, no. 5, pp. 235-241. https://doi.org/10.1016/S0968-0004(02)02085-6

The SOCS box : A tale of destruction and degradation. / Kile, Benjamin T.; Schulman, Brenda A.; Alexander, Warren S.; Nicola, Nicos A.; Martin, Helene M.E.; Hilton, Douglas J.

In: Trends in Biochemical Sciences, Vol. 27, No. 5, 01.05.2002, p. 235-241.

Research output: Contribution to journalReview ArticleResearchpeer-review

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Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HME, Hilton DJ. The SOCS box: A tale of destruction and degradation. Trends in Biochemical Sciences. 2002 May 1;27(5):235-241. https://doi.org/10.1016/S0968-0004(02)02085-6