The snake venom toxin alboaggregin-A activates glycoprotein VI

Naoki Asazuma, Stuart J. Marshall, Oscar Berlanga, Daniel Snell, Alastair W. Poole, Michael C. Berndt, Robert K. Andrews, Steve P. Watson

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27 Citations (Scopus)

Abstract

The glycoprotein (GP)-lb-IX-V receptor complex has recently been reported to signal through a pathway similar to that used by the collagen receptor GPVI, with a critical role described for the Fc receptor γ-chain. The evidence for this was based in part on studies with the GPlbα-selective snake venom toxin, alboaggregin-A. In the present study, it is reported that alboaggregin-A has activity at the Collagen receptor GPVI in addition to GPlbα, and evidence is provided that this contributes to protein tyrosine phosphorylation, shape change, and GPlb-llla-dependent aggregation. This may explain why responses to alboaggregin-A are distinct from those to von Willebrand factor-ristocetin.

Original languageEnglish
Pages (from-to)3989-3991
Number of pages3
JournalBlood
Volume97
Issue number12
DOIs
Publication statusPublished - 15 Jun 2001
Externally publishedYes

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