The snake venom toxin alboaggregin-A activates glycoprotein VI

Naoki Asazuma; Stuart J. Marshall; Oscar Berlanga; Daniel Snell; Alastair W. Poole; Michael C. Berndt; Robert K. Andrews; Steve P. Watson

doi:10.1182/blood.V97.12.3989

The snake venom toxin alboaggregin-A activates glycoprotein VI

Naoki Asazuma, Stuart J. Marshall, Oscar Berlanga, Daniel Snell, Alastair W. Poole, Michael C. Berndt, Robert K. Andrews, Steve P. Watson

Research output: Contribution to journal › Article › Research › peer-review

27 Citations (Scopus)

Abstract

The glycoprotein (GP)-lb-IX-V receptor complex has recently been reported to signal through a pathway similar to that used by the collagen receptor GPVI, with a critical role described for the Fc receptor γ-chain. The evidence for this was based in part on studies with the GPlbα-selective snake venom toxin, alboaggregin-A. In the present study, it is reported that alboaggregin-A has activity at the Collagen receptor GPVI in addition to GPlbα, and evidence is provided that this contributes to protein tyrosine phosphorylation, shape change, and GPlb-llla-dependent aggregation. This may explain why responses to alboaggregin-A are distinct from those to von Willebrand factor-ristocetin.

Original language	English
Pages (from-to)	3989-3991
Number of pages	3
Journal	Blood
Volume	97
Issue number	12
DOIs	https://doi.org/10.1182/blood.V97.12.3989
Publication status	Published - 15 Jun 2001
Externally published	Yes

Access to Document

10.1182/blood.V97.12.3989

Link to publication in Scopus

Cite this

@article{81dcefae42ba47d393f2aa191cd50f68,

title = "The snake venom toxin alboaggregin-A activates glycoprotein VI",

abstract = "The glycoprotein (GP)-lb-IX-V receptor complex has recently been reported to signal through a pathway similar to that used by the collagen receptor GPVI, with a critical role described for the Fc receptor γ-chain. The evidence for this was based in part on studies with the GPlbα-selective snake venom toxin, alboaggregin-A. In the present study, it is reported that alboaggregin-A has activity at the Collagen receptor GPVI in addition to GPlbα, and evidence is provided that this contributes to protein tyrosine phosphorylation, shape change, and GPlb-llla-dependent aggregation. This may explain why responses to alboaggregin-A are distinct from those to von Willebrand factor-ristocetin.",

author = "Naoki Asazuma and Marshall, {Stuart J.} and Oscar Berlanga and Daniel Snell and Poole, {Alastair W.} and Berndt, {Michael C.} and Andrews, {Robert K.} and Watson, {Steve P.}",

year = "2001",

month = jun,

day = "15",

doi = "10.1182/blood.V97.12.3989",

language = "English",

volume = "97",

pages = "3989--3991",

journal = "Blood",

issn = "0006-4971",

publisher = "American Society of Hematology",

number = "12",

}

TY - JOUR

T1 - The snake venom toxin alboaggregin-A activates glycoprotein VI

AU - Asazuma, Naoki

AU - Marshall, Stuart J.

AU - Berlanga, Oscar

AU - Snell, Daniel

AU - Poole, Alastair W.

AU - Berndt, Michael C.

AU - Andrews, Robert K.

AU - Watson, Steve P.

PY - 2001/6/15

Y1 - 2001/6/15

N2 - The glycoprotein (GP)-lb-IX-V receptor complex has recently been reported to signal through a pathway similar to that used by the collagen receptor GPVI, with a critical role described for the Fc receptor γ-chain. The evidence for this was based in part on studies with the GPlbα-selective snake venom toxin, alboaggregin-A. In the present study, it is reported that alboaggregin-A has activity at the Collagen receptor GPVI in addition to GPlbα, and evidence is provided that this contributes to protein tyrosine phosphorylation, shape change, and GPlb-llla-dependent aggregation. This may explain why responses to alboaggregin-A are distinct from those to von Willebrand factor-ristocetin.

AB - The glycoprotein (GP)-lb-IX-V receptor complex has recently been reported to signal through a pathway similar to that used by the collagen receptor GPVI, with a critical role described for the Fc receptor γ-chain. The evidence for this was based in part on studies with the GPlbα-selective snake venom toxin, alboaggregin-A. In the present study, it is reported that alboaggregin-A has activity at the Collagen receptor GPVI in addition to GPlbα, and evidence is provided that this contributes to protein tyrosine phosphorylation, shape change, and GPlb-llla-dependent aggregation. This may explain why responses to alboaggregin-A are distinct from those to von Willebrand factor-ristocetin.

UR - http://www.scopus.com/inward/record.url?scp=0035877964&partnerID=8YFLogxK

U2 - 10.1182/blood.V97.12.3989

DO - 10.1182/blood.V97.12.3989

M3 - Article

C2 - 11389045

AN - SCOPUS:0035877964

VL - 97

SP - 3989

EP - 3991

JO - Blood

JF - Blood

SN - 0006-4971

IS - 12

ER -