The single‐point method of dosage prediction: Pharmacokinetic basis and method optimization

B. L. Love, S. E. Tsuei, J. Thomas, R. L. Nation

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Based on the principle of superposition an expression has been established relating a drug concentration at steady‐state to a concentration after a single dose. This relationship applies for drugs with linear pharmacokinetics given at equal dosage intervals and it is independent of the route of administration. The relationship provides theoretical justification for the single‐point method of dosage prediction reported in the literature. The test conditions in the method can therefore be optimized and the limits of the method defined. The expression can also be used for individualized prediction of maintenance dose after estimation of drug half‐life in the patient with no limit to half‐life values to which it can be applied.

Original languageEnglish
Pages (from-to)191-201
Number of pages11
JournalBiopharmaceutics & Drug Disposition
Volume3
Issue number3
DOIs
Publication statusPublished - 1 Jan 1982

Keywords

  • Dosage
  • Pharmacokinetics
  • Prediction
  • Single‐point

Cite this

@article{69fc9a2ab2af46c590f84364f3583d41,
title = "The single‐point method of dosage prediction: Pharmacokinetic basis and method optimization",
abstract = "Based on the principle of superposition an expression has been established relating a drug concentration at steady‐state to a concentration after a single dose. This relationship applies for drugs with linear pharmacokinetics given at equal dosage intervals and it is independent of the route of administration. The relationship provides theoretical justification for the single‐point method of dosage prediction reported in the literature. The test conditions in the method can therefore be optimized and the limits of the method defined. The expression can also be used for individualized prediction of maintenance dose after estimation of drug half‐life in the patient with no limit to half‐life values to which it can be applied.",
keywords = "Dosage, Pharmacokinetics, Prediction, Single‐point",
author = "Love, {B. L.} and Tsuei, {S. E.} and J. Thomas and Nation, {R. L.}",
year = "1982",
month = "1",
day = "1",
doi = "10.1002/bdd.2510030302",
language = "English",
volume = "3",
pages = "191--201",
journal = "Biopharmaceutics and Drug Disposition",
issn = "0142-2782",
publisher = "Wiley-Blackwell",
number = "3",

}

The single‐point method of dosage prediction : Pharmacokinetic basis and method optimization. / Love, B. L.; Tsuei, S. E.; Thomas, J.; Nation, R. L.

In: Biopharmaceutics & Drug Disposition, Vol. 3, No. 3, 01.01.1982, p. 191-201.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - The single‐point method of dosage prediction

T2 - Pharmacokinetic basis and method optimization

AU - Love, B. L.

AU - Tsuei, S. E.

AU - Thomas, J.

AU - Nation, R. L.

PY - 1982/1/1

Y1 - 1982/1/1

N2 - Based on the principle of superposition an expression has been established relating a drug concentration at steady‐state to a concentration after a single dose. This relationship applies for drugs with linear pharmacokinetics given at equal dosage intervals and it is independent of the route of administration. The relationship provides theoretical justification for the single‐point method of dosage prediction reported in the literature. The test conditions in the method can therefore be optimized and the limits of the method defined. The expression can also be used for individualized prediction of maintenance dose after estimation of drug half‐life in the patient with no limit to half‐life values to which it can be applied.

AB - Based on the principle of superposition an expression has been established relating a drug concentration at steady‐state to a concentration after a single dose. This relationship applies for drugs with linear pharmacokinetics given at equal dosage intervals and it is independent of the route of administration. The relationship provides theoretical justification for the single‐point method of dosage prediction reported in the literature. The test conditions in the method can therefore be optimized and the limits of the method defined. The expression can also be used for individualized prediction of maintenance dose after estimation of drug half‐life in the patient with no limit to half‐life values to which it can be applied.

KW - Dosage

KW - Pharmacokinetics

KW - Prediction

KW - Single‐point

UR - http://www.scopus.com/inward/record.url?scp=0019980004&partnerID=8YFLogxK

U2 - 10.1002/bdd.2510030302

DO - 10.1002/bdd.2510030302

M3 - Article

VL - 3

SP - 191

EP - 201

JO - Biopharmaceutics and Drug Disposition

JF - Biopharmaceutics and Drug Disposition

SN - 0142-2782

IS - 3

ER -