The sheep analogue of leucocyte common antigen (LCA)

J. F. Maddox, C. R. Mackay, M. R. Brandon

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Abstract

The tissue distribution and immunochemical properties of antigens recognized by two monoclonal antibodies 1.11.32 and 1.28.124 define the sheep analogue of the leucocyte common antigen found in rat, man and mouse. Histological and immunofluorescent studies show that this antigen is found on all lymphocytes, as well as other leucocytes but is absent from non-leucocytic cells. Immunochemical data show that a series of proteins of high molecular weight (190,000-225,000) are recognized, and histological studies show the presence of this antigen on a subpopulation of fetal liver cells as early as Day 27-30 of gestation, and on all fetal thymocytes from Day 40 of gestation.

Original languageEnglish
Pages (from-to)347-353
Number of pages7
JournalImmunology
Volume55
Issue number2
Publication statusPublished - 1 Jan 1985
Externally publishedYes

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