The seroprevalence and seroincidence of enterovirus71 infection in infants and children in Ho Chi Minh City, Viet Nam

Chau Bich Nguyen Tran, Trong Hieu Nguyen, Ha Thanh Thi Phan, Van Ngoc Tran, Bridget Wills, Jeremy Farrar, Joseph D. Santangelo, Cameron P. Simmons

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39 Citations (Scopus)

Abstract

Enterovirus 71 (EV71)-associated hand, foot and mouth disease has emerged as a serious public health problem in South East Asia over the last decade. To better understand the prevalence of EV71 infection, we determined EV71 seroprevalence and seroincidence amongst healthy infants and children in Ho Chi Minh City, Viet Nam. In a cohort of 200 newborns, 55% of cord blood samples contained EV71 neutralizing antibodies and these decayed to undetectable levels by 6 months of age in 98% of infants. The EV71 neutralizing antibody seroconversion rate was 5.6% in the first year and 14% in the second year of life. In children 5-15 yrs of age, seroprevalence of EV71 neutralizing antibodies was 84% and in cord blood it was 55%. Taken together, these data suggest EV71 force of infection is high and highlights the need for more research into its epidemiology and pathogenesis in high disease burden countries.

Original languageEnglish
Article numbere21116
JournalPLoS ONE
Volume6
Issue number7
DOIs
Publication statusPublished - 2011
Externally publishedYes

Cite this

Tran, C. B. N., Nguyen, T. H., Phan, H. T. T., Tran, V. N., Wills, B., Farrar, J., Santangelo, J. D., & Simmons, C. P. (2011). The seroprevalence and seroincidence of enterovirus71 infection in infants and children in Ho Chi Minh City, Viet Nam. PLoS ONE, 6(7), [e21116]. https://doi.org/10.1371/journal.pone.0021116