The roles of juvenile hormone, insulin/target of rapamycin, and ecydsone signaling in regulating body size in Drosophila

Christen Kerry Mirth; Alexander Shingleton

doi:10.4161/cib.29240

The roles of juvenile hormone, insulin/target of rapamycin, and ecydsone signaling in regulating body size in Drosophila

Christen Kerry Mirth, Alexander Shingleton

Research output: Contribution to journal › Article › Other › peer-review

15 Citations (Scopus)

Abstract

Understanding how organisms regulate their body size has interested biologists for decades. Recent work has shown that both insulin/target of rapamycin (TOR) signaling and the steroid hormone ecdysone act to regulate rates of growth and the duration of the growth period in the fruit fly, Drosophila melanogaster. Our recent work has uncovered a third level of interaction, whereby juvenile hormone (JH) regulates levels of both ecdysone and insulin/TOR signaling to control growth rates. These studies highlight a complex network of interactions involved in regulating body and organ size.

Original language	English
Pages (from-to)	1-3
Number of pages	3
Journal	Communicative and Integrative Biology
Volume	7
Issue number	5
DOIs	https://doi.org/10.4161/cib.29240
Publication status	Published - 2014
Externally published	Yes

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10.4161/cib.29240

Cite this

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