The role of vitamin D and P2X7R in multiple sclerosis

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Abstract

Multiple sclerosis (MS) is characterized by neuroinflammatory infiltrates and central nervous system demyelination. In the neuroinflammatory foci of MS there is increased expression of a purinergic receptor, P2X7R. Although implicated in the neuroinflammation, the exact role of P2X7R in the context of MS is unclear and forms the basis of this review. In this review, we also introduce the immunopathologies and inflammatory processes in MS, with a focus on P2X7R and the possible immunomodulatory role of vitamin D deficiency in this setting.

Original languageEnglish
Pages (from-to)159-169
Number of pages11
JournalJournal of Neuroimmunology
Volume330
DOIs
Publication statusPublished - 15 May 2019

Keywords

  • Innate immunity
  • Monocytes
  • Multiple sclerosis
  • Neuroinflammation
  • P2X7R
  • Vitamin D

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