The role of vitamin D and P2X7R in multiple sclerosis

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Multiple sclerosis (MS) is characterized by neuroinflammatory infiltrates and central nervous system demyelination. In the neuroinflammatory foci of MS there is increased expression of a purinergic receptor, P2X7R. Although implicated in the neuroinflammation, the exact role of P2X7R in the context of MS is unclear and forms the basis of this review. In this review, we also introduce the immunopathologies and inflammatory processes in MS, with a focus on P2X7R and the possible immunomodulatory role of vitamin D deficiency in this setting.

Original languageEnglish
Pages (from-to)159-169
Number of pages11
JournalJournal of Neuroimmunology
Volume330
DOIs
Publication statusPublished - 15 May 2019

Keywords

  • Innate immunity
  • Monocytes
  • Multiple sclerosis
  • Neuroinflammation
  • P2X7R
  • Vitamin D

Cite this

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title = "The role of vitamin D and P2X7R in multiple sclerosis",
abstract = "Multiple sclerosis (MS) is characterized by neuroinflammatory infiltrates and central nervous system demyelination. In the neuroinflammatory foci of MS there is increased expression of a purinergic receptor, P2X7R. Although implicated in the neuroinflammation, the exact role of P2X7R in the context of MS is unclear and forms the basis of this review. In this review, we also introduce the immunopathologies and inflammatory processes in MS, with a focus on P2X7R and the possible immunomodulatory role of vitamin D deficiency in this setting.",
keywords = "Innate immunity, Monocytes, Multiple sclerosis, Neuroinflammation, P2X7R, Vitamin D",
author = "Voo, {Veronica Tsin Fong} and Terence O'Brien and Helmut Butzkueven and Mastura Monif",
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The role of vitamin D and P2X7R in multiple sclerosis. / Voo, Veronica Tsin Fong; O'Brien, Terence; Butzkueven, Helmut; Monif, Mastura.

In: Journal of Neuroimmunology, Vol. 330, 15.05.2019, p. 159-169.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - The role of vitamin D and P2X7R in multiple sclerosis

AU - Voo, Veronica Tsin Fong

AU - O'Brien, Terence

AU - Butzkueven, Helmut

AU - Monif, Mastura

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AB - Multiple sclerosis (MS) is characterized by neuroinflammatory infiltrates and central nervous system demyelination. In the neuroinflammatory foci of MS there is increased expression of a purinergic receptor, P2X7R. Although implicated in the neuroinflammation, the exact role of P2X7R in the context of MS is unclear and forms the basis of this review. In this review, we also introduce the immunopathologies and inflammatory processes in MS, with a focus on P2X7R and the possible immunomodulatory role of vitamin D deficiency in this setting.

KW - Innate immunity

KW - Monocytes

KW - Multiple sclerosis

KW - Neuroinflammation

KW - P2X7R

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