The role of vitamin D and P2X7R in multiple sclerosis

Veronica Tsin Fong Voo; Terence O'Brien; Helmut Butzkueven; Mastura Monif

doi:10.1016/j.jneuroim.2019.03.004

The role of vitamin D and P2X7R in multiple sclerosis

Veronica Tsin Fong Voo, Terence O'Brien, Helmut Butzkueven, Mastura Monif

Research output: Contribution to journal › Review Article › Research › peer-review

7 Citations (Scopus)

Abstract

Multiple sclerosis (MS) is characterized by neuroinflammatory infiltrates and central nervous system demyelination. In the neuroinflammatory foci of MS there is increased expression of a purinergic receptor, P2X7R. Although implicated in the neuroinflammation, the exact role of P2X7R in the context of MS is unclear and forms the basis of this review. In this review, we also introduce the immunopathologies and inflammatory processes in MS, with a focus on P2X7R and the possible immunomodulatory role of vitamin D deficiency in this setting.

Original language	English
Pages (from-to)	159-169
Number of pages	11
Journal	Journal of Neuroimmunology
Volume	330
DOIs	https://doi.org/10.1016/j.jneuroim.2019.03.004
Publication status	Published - 15 May 2019

Keywords

Innate immunity
Monocytes
Multiple sclerosis
Neuroinflammation
P2X7R
Vitamin D

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10.1016/j.jneuroim.2019.03.004

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title = "The role of vitamin D and P2X7R in multiple sclerosis",

abstract = "Multiple sclerosis (MS) is characterized by neuroinflammatory infiltrates and central nervous system demyelination. In the neuroinflammatory foci of MS there is increased expression of a purinergic receptor, P2X7R. Although implicated in the neuroinflammation, the exact role of P2X7R in the context of MS is unclear and forms the basis of this review. In this review, we also introduce the immunopathologies and inflammatory processes in MS, with a focus on P2X7R and the possible immunomodulatory role of vitamin D deficiency in this setting.",

keywords = "Innate immunity, Monocytes, Multiple sclerosis, Neuroinflammation, P2X7R, Vitamin D",

author = "Voo, {Veronica Tsin Fong} and Terence O'Brien and Helmut Butzkueven and Mastura Monif",

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T1 - The role of vitamin D and P2X7R in multiple sclerosis

AU - Voo, Veronica Tsin Fong

AU - O'Brien, Terence

AU - Butzkueven, Helmut

AU - Monif, Mastura

PY - 2019/5/15

Y1 - 2019/5/15

N2 - Multiple sclerosis (MS) is characterized by neuroinflammatory infiltrates and central nervous system demyelination. In the neuroinflammatory foci of MS there is increased expression of a purinergic receptor, P2X7R. Although implicated in the neuroinflammation, the exact role of P2X7R in the context of MS is unclear and forms the basis of this review. In this review, we also introduce the immunopathologies and inflammatory processes in MS, with a focus on P2X7R and the possible immunomodulatory role of vitamin D deficiency in this setting.

AB - Multiple sclerosis (MS) is characterized by neuroinflammatory infiltrates and central nervous system demyelination. In the neuroinflammatory foci of MS there is increased expression of a purinergic receptor, P2X7R. Although implicated in the neuroinflammation, the exact role of P2X7R in the context of MS is unclear and forms the basis of this review. In this review, we also introduce the immunopathologies and inflammatory processes in MS, with a focus on P2X7R and the possible immunomodulatory role of vitamin D deficiency in this setting.

KW - Innate immunity

KW - Monocytes

KW - Multiple sclerosis

KW - Neuroinflammation

KW - P2X7R

KW - Vitamin D

UR - http://www.scopus.com/inward/record.url?scp=85063346895&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2019.03.004

DO - 10.1016/j.jneuroim.2019.03.004

M3 - Review Article

C2 - 30908981

AN - SCOPUS:85063346895

SN - 0165-5728

VL - 330

SP - 159

EP - 169

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

The role of vitamin D and P2X7R in multiple sclerosis

Abstract

Keywords

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