El papel de la investigación translacional en la enfermedad inflamatoria intestinal

Translated title of the contribution: The role of translational research in inflammatory bowel disease

María T. Abreu, Miles P. Sparrow

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)


The idiopathic inflammatory bowel diseases, broadly classified as either Crohn's disease or ulcerative colitis, are caused by a dysregulated mucosal immune response to a luminal antigen, possibly a bacterium, in a genetically predisposed host. A rapid expansion of knowledge in recent years has greatly increased our understanding of the pathophysiology of these disorders. For example, the relatively recent discovery of the NOD2 gene, a protein involved in bacterial sensing, has provided further evidence of the complex interplay between hosts and microbes in Crohn's disease. Significant recent advances have also occurred with the discovery of the role of Toll-like receptors and dendritic cells in the development of gut inflammation, and the role of proinflammatory cytokines in the development and potentiation of gut inflammation. This article presents an update on these key developments and emphasizes the translational aspects of research that are directly related to patient care.

Translated title of the contributionThe role of translational research in inflammatory bowel disease
Original languageSpanish
Pages (from-to)146-153
Number of pages8
JournalRevista de Gastroenterologia de Mexico
Issue number2
Publication statusPublished - Apr 2007
Externally publishedYes

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