The role of toxin A and toxin B in the virulence of clostridium difficile

Glen P Carter, Julian I Rood, Dena Lyras

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113 Citations (Scopus)

Abstract

During the past decade, there has been a striking increase in Clostridium difficile nosocomial infections worldwide predominantly due to the emergence of epidemic or hypervirulent isolates, leading to an increased research focus on this bacterium. Particular interest has surrounded the two large clostridial toxins encoded by most virulent isolates, known as toxin A and toxin B. Toxin A was thought to be the major virulence factor for many years; however, it is becoming increasingly evident that toxin B plays a much more important role than anticipated. It is clear that further experiments are required to accurately determine the relative roles of each toxin in disease, especially in more clinically relevant current epidemic isolates.
Original languageEnglish
Pages (from-to)21 - 29
Number of pages9
JournalTrends in Microbiology
Volume20
Issue number1
DOIs
Publication statusPublished - 2012

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