The role of toll-like receptors in macrophages

Claire McCoy, Luke O'Neill

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)


Macrophages play diverse roles including but not limited to homeostatic clearance, detection of invading pathogens and induction of the adaptive immune response. Since their discovery, it has become clear that Toll-like receptors (TLRs) can play a major role in these macrophage functions. This review will describe the TLRs, their signalling pathways and their role in macrophage function.
Original languageEnglish
Pages (from-to)62 - 70
Number of pages9
JournalFrontiers in Bioscience
Publication statusPublished - 2008
Externally publishedYes

Cite this