Abstract
The objectives of this study were to determine whether leptin synthesis is regulated by the sympathetic nervous system and if so whether β-adrenergic receptors mediate this effect. We show that sympathetic blockade by reserpine increases leptin mRNA levels in brown but not white adipose tissue, while acute cold-exposure decreases leptin expression 10-fold in brown adipose tissue and 2-fold in white adipose tissue. The cold-induced reduction in leptin mRNA can be prevented by a combination of propranolol and SR 59230A but not by either antagonist alone, indicating that β3-adrenergic receptors and classical β1/β2-adrenergic receptors both mediate responses to sympathetic stimulation. Circulating leptin levels reflect synthesis in white adipose tissue but not in brown adipose tissue. Copyright (C) 1999 Federation of European Biochemical Societies.
| Original language | English |
|---|---|
| Pages (from-to) | 149-154 |
| Number of pages | 6 |
| Journal | FEBS Letters |
| Volume | 444 |
| Issue number | 2-3 |
| DOIs | |
| Publication status | Published - 12 Feb 1999 |
Keywords
- β/β-Adrenoceptor
- β-Adrenoceptor
- Leptin
- Sympathetic nervous system
Cite this
}
The role of the sympathetic nervous system in the regulation of leptin synthesis in C57BL/6 mice. / Evans, Bronwyn A; Agar, Larissa; Summers, Roger J.
In: FEBS Letters, Vol. 444, No. 2-3, 12.02.1999, p. 149-154.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - The role of the sympathetic nervous system in the regulation of leptin synthesis in C57BL/6 mice
AU - Evans, Bronwyn A
AU - Agar, Larissa
AU - Summers, Roger J
PY - 1999/2/12
Y1 - 1999/2/12
N2 - The objectives of this study were to determine whether leptin synthesis is regulated by the sympathetic nervous system and if so whether β-adrenergic receptors mediate this effect. We show that sympathetic blockade by reserpine increases leptin mRNA levels in brown but not white adipose tissue, while acute cold-exposure decreases leptin expression 10-fold in brown adipose tissue and 2-fold in white adipose tissue. The cold-induced reduction in leptin mRNA can be prevented by a combination of propranolol and SR 59230A but not by either antagonist alone, indicating that β3-adrenergic receptors and classical β1/β2-adrenergic receptors both mediate responses to sympathetic stimulation. Circulating leptin levels reflect synthesis in white adipose tissue but not in brown adipose tissue. Copyright (C) 1999 Federation of European Biochemical Societies.
AB - The objectives of this study were to determine whether leptin synthesis is regulated by the sympathetic nervous system and if so whether β-adrenergic receptors mediate this effect. We show that sympathetic blockade by reserpine increases leptin mRNA levels in brown but not white adipose tissue, while acute cold-exposure decreases leptin expression 10-fold in brown adipose tissue and 2-fold in white adipose tissue. The cold-induced reduction in leptin mRNA can be prevented by a combination of propranolol and SR 59230A but not by either antagonist alone, indicating that β3-adrenergic receptors and classical β1/β2-adrenergic receptors both mediate responses to sympathetic stimulation. Circulating leptin levels reflect synthesis in white adipose tissue but not in brown adipose tissue. Copyright (C) 1999 Federation of European Biochemical Societies.
KW - β/β-Adrenoceptor
KW - β-Adrenoceptor
KW - Leptin
KW - Sympathetic nervous system
UR - http://www.scopus.com/inward/record.url?scp=0033002267&partnerID=8YFLogxK
U2 - 10.1016/S0014-5793(99)00049-6
DO - 10.1016/S0014-5793(99)00049-6
M3 - Article
VL - 444
SP - 149
EP - 154
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 2-3
ER -