The role of the intrinsic apoptosis pathway in platelet life and death

Research output: Contribution to journalReview ArticleResearchpeer-review

49 Citations (Scopus)

Abstract

In recent years, it has become increasingly apparent that the production of platelets and their subsequent life span in the circulation are regulated, at least in part, by apoptotic mechanisms. There is also evidence implicating the apoptotic machinery in the regulation of platelet functional responses. This review examines the role of the intrinsic apoptosis pathway, regulated by the Bcl-2 family of proteins, in platelet biology.

Original languageEnglish
Pages (from-to)214-217
Number of pages4
JournalJournal of Thrombosis and Haemostasis
Volume7
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 2009
Externally publishedYes

Keywords

  • Apoptosis
  • Bcl-2
  • Megakaryocyte
  • Platelet

Cite this

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title = "The role of the intrinsic apoptosis pathway in platelet life and death",
abstract = "In recent years, it has become increasingly apparent that the production of platelets and their subsequent life span in the circulation are regulated, at least in part, by apoptotic mechanisms. There is also evidence implicating the apoptotic machinery in the regulation of platelet functional responses. This review examines the role of the intrinsic apoptosis pathway, regulated by the Bcl-2 family of proteins, in platelet biology.",
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The role of the intrinsic apoptosis pathway in platelet life and death. / Kile, Benjamin T.

In: Journal of Thrombosis and Haemostasis, Vol. 7, No. SUPPL. 1, 2009, p. 214-217.

Research output: Contribution to journalReview ArticleResearchpeer-review

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AB - In recent years, it has become increasingly apparent that the production of platelets and their subsequent life span in the circulation are regulated, at least in part, by apoptotic mechanisms. There is also evidence implicating the apoptotic machinery in the regulation of platelet functional responses. This review examines the role of the intrinsic apoptosis pathway, regulated by the Bcl-2 family of proteins, in platelet biology.

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