The Role of the Interleukin-1 Family in Complications of Prematurity

Elys A. Green, Steven P. Garrick, Briana Peterson, Philip J. Berger, Robert Galinsky, Rod W. Hunt, Steven X. Cho, Jane E. Bourke, Marcel F. Nold, Claudia A. Nold-Petry

Research output: Contribution to journalReview ArticleResearchpeer-review

10 Citations (Scopus)


Preterm birth is a major contributor to neonatal morbidity and mortality. Complications of prematurity such as bronchopulmonary dysplasia (BPD, affecting the lung), pulmonary hypertension associated with BPD (BPD-PH, heart), white matter injury (WMI, brain), retinopathy of prematurity (ROP, eyes), necrotizing enterocolitis (NEC, gut) and sepsis are among the major causes of long-term morbidity in infants born prematurely. Though the origins are multifactorial, inflammation and in particular the imbalance of pro- and anti-inflammatory mediators is now recognized as a key driver of the pathophysiology underlying these illnesses. Here, we review the involvement of the interleukin (IL)-1 family in perinatal inflammation and its clinical implications, with a focus on the potential of these cytokines as therapeutic targets for the development of safe and effective treatments for early life inflammatory diseases.

Original languageEnglish
Article number2795
Number of pages29
JournalInternational Journal of Molecular Sciences
Issue number3
Publication statusPublished - Feb 2023


  • bronchopulmonary dysplasia
  • cerebral palsy
  • IL-1
  • IL-18
  • IL-1Ra
  • IL-33
  • IL-36
  • IL-36Ra
  • IL-37
  • IL-38
  • inflammation
  • necrotizing enterocolitis
  • prematurity
  • pulmonary hypertension
  • retinopathy of prematurity
  • sepsis
  • white matter injury

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