The Role of the BAFF and Lymphotoxin Pathways in B Cell Biology

Fabienne Mackay, Jennifer L. Gommerman

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Abstract

The tumor necrosis factor (TNF) superfamily plays an important role in the homeostasis and activation of the immune system during development and in the adult. Although the CD40 TNF superfamily member is critical for the intrinsic activation of B cells within germinal centers, other TNF superfamily members such as lymphotoxin and B cell activating factor of tumor necrosis factor (BAFF) are required to shape the environment in which B cells are activated. Specifically, constitutive signaling through the lymphotoxin beta receptor (LTβR) is required to maintain functional aspects of the stromal cells that underpin B cell-rich niches whereas BAFF receptor signaling is critical for the survival of particular B cell subsets. Integration of BAFF- and LTβR-derived signals is key for the generation of an appropriate B cell response to foreign pathogens, and therapeutic targeting of these pathways has the potential to ameliorate disease states in which B cells play a central role.

Original languageEnglish
Title of host publicationMolecular Biology of B Cells
EditorsTasuku Honjo, Michael Reth, Andreas Radbruch, Frederick Alt
Place of PublicationLondon, UK
PublisherElsevier
Chapter15
Pages251-276
Number of pages26
Edition2nd
ISBN (Electronic)9780123984906
ISBN (Print)9780123979339
Publication statusPublished - 15 Dec 2014

Keywords

  • APRIL
  • Autoimmunity
  • BAFF
  • Follicular dendritic cell (FDC)
  • Germinal center
  • Homeostasis
  • Lymphotoxin (LT)
  • Plasma cell
  • TACI

Cite this

Mackay, F., & Gommerman, J. L. (2014). The Role of the BAFF and Lymphotoxin Pathways in B Cell Biology. In T. Honjo, M. Reth, A. Radbruch, & F. Alt (Eds.), Molecular Biology of B Cells (2nd ed., pp. 251-276). London, UK: Elsevier.
Mackay, Fabienne ; Gommerman, Jennifer L. / The Role of the BAFF and Lymphotoxin Pathways in B Cell Biology. Molecular Biology of B Cells. editor / Tasuku Honjo ; Michael Reth ; Andreas Radbruch ; Frederick Alt. 2nd. ed. London, UK : Elsevier, 2014. pp. 251-276
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Mackay, F & Gommerman, JL 2014, The Role of the BAFF and Lymphotoxin Pathways in B Cell Biology. in T Honjo, M Reth, A Radbruch & F Alt (eds), Molecular Biology of B Cells. 2nd edn, Elsevier, London, UK, pp. 251-276.

The Role of the BAFF and Lymphotoxin Pathways in B Cell Biology. / Mackay, Fabienne; Gommerman, Jennifer L.

Molecular Biology of B Cells. ed. / Tasuku Honjo; Michael Reth; Andreas Radbruch; Frederick Alt. 2nd. ed. London, UK : Elsevier, 2014. p. 251-276.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

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N2 - The tumor necrosis factor (TNF) superfamily plays an important role in the homeostasis and activation of the immune system during development and in the adult. Although the CD40 TNF superfamily member is critical for the intrinsic activation of B cells within germinal centers, other TNF superfamily members such as lymphotoxin and B cell activating factor of tumor necrosis factor (BAFF) are required to shape the environment in which B cells are activated. Specifically, constitutive signaling through the lymphotoxin beta receptor (LTβR) is required to maintain functional aspects of the stromal cells that underpin B cell-rich niches whereas BAFF receptor signaling is critical for the survival of particular B cell subsets. Integration of BAFF- and LTβR-derived signals is key for the generation of an appropriate B cell response to foreign pathogens, and therapeutic targeting of these pathways has the potential to ameliorate disease states in which B cells play a central role.

AB - The tumor necrosis factor (TNF) superfamily plays an important role in the homeostasis and activation of the immune system during development and in the adult. Although the CD40 TNF superfamily member is critical for the intrinsic activation of B cells within germinal centers, other TNF superfamily members such as lymphotoxin and B cell activating factor of tumor necrosis factor (BAFF) are required to shape the environment in which B cells are activated. Specifically, constitutive signaling through the lymphotoxin beta receptor (LTβR) is required to maintain functional aspects of the stromal cells that underpin B cell-rich niches whereas BAFF receptor signaling is critical for the survival of particular B cell subsets. Integration of BAFF- and LTβR-derived signals is key for the generation of an appropriate B cell response to foreign pathogens, and therapeutic targeting of these pathways has the potential to ameliorate disease states in which B cells play a central role.

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KW - Autoimmunity

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KW - TACI

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BT - Molecular Biology of B Cells

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Mackay F, Gommerman JL. The Role of the BAFF and Lymphotoxin Pathways in B Cell Biology. In Honjo T, Reth M, Radbruch A, Alt F, editors, Molecular Biology of B Cells. 2nd ed. London, UK: Elsevier. 2014. p. 251-276