The role of stem cell transplantation in the management of chronic lymphocytic leukaemia

Constantine S. Tam; Issa Khouri

doi:10.1002/hon.884

The role of stem cell transplantation in the management of chronic lymphocytic leukaemia

Constantine S. Tam, Issa Khouri

Research output: Contribution to journal › Review Article › Research › peer-review

8 Citations (Scopus)

Abstract

The majority of patients diagnosed with chronic lymphocytic leukaemia (CLL) will ultimately die of their disease. Stem cell transplantation (SCT) remains the only treatment modality capable of cure, but has traditionally been associated with very high morbidity and mortality. We review the results of myeloablative autologous and allogeneic SCT in CLL, discuss the evolution of the new non-myeloablative approaches, and make recommendations for when SCT should be considered in patients with CLL.

Original language	English
Pages (from-to)	53-60
Number of pages	8
Journal	Hematological Oncology
Volume	27
Issue number	2
DOIs	https://doi.org/10.1002/hon.884
Publication status	Published - 2009
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Alemtuzumab
Bone marrow transplantation
Reduced intensity conditioning
Rituximab

Access to Document

10.1002/hon.884

Cite this

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abstract = "The majority of patients diagnosed with chronic lymphocytic leukaemia (CLL) will ultimately die of their disease. Stem cell transplantation (SCT) remains the only treatment modality capable of cure, but has traditionally been associated with very high morbidity and mortality. We review the results of myeloablative autologous and allogeneic SCT in CLL, discuss the evolution of the new non-myeloablative approaches, and make recommendations for when SCT should be considered in patients with CLL.",

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AB - The majority of patients diagnosed with chronic lymphocytic leukaemia (CLL) will ultimately die of their disease. Stem cell transplantation (SCT) remains the only treatment modality capable of cure, but has traditionally been associated with very high morbidity and mortality. We review the results of myeloablative autologous and allogeneic SCT in CLL, discuss the evolution of the new non-myeloablative approaches, and make recommendations for when SCT should be considered in patients with CLL.

KW - Alemtuzumab

KW - Bone marrow transplantation

KW - Reduced intensity conditioning

KW - Rituximab

UR - https://www.scopus.com/pages/publications/66949144744

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M3 - Review Article

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JF - Hematological Oncology

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ER -

The role of stem cell transplantation in the management of chronic lymphocytic leukaemia

Abstract

UN SDGs

Keywords

Access to Document

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