Patterning and differentiation along the dorsal-ventral(D-V) axis lead to cloacal partitioning into ventral urinary and dorsal alimentary tracts in most mammals, but not birds and fish. We previously reported that the major activator of Sonic hedgehog (Shh) signaling transcription factor Gli2 plays an essentail role in clocoal partitioning along the D-V axis in a mouse model. Here, we report that chick cloacal patterning and differentiation is along the anterior-posterior axis.
|Pages (from-to)||448 - 460|
|Number of pages||13|
|Publication status||Published - 2007|