The role of serpins in vertebrate immunity

Matthew Mangan, Dion Kaiserman, Phillip Ian Bird

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)


Serine proteases are important components of the immune system, playing a role in many processes including migration, phagocytosis and elimination of virally infected and cancerous cells. Members of the serpin superfamily regulate the activity of these proteases to limit tissue damage and unwarranted cell death. This review focuses on the role of intracellular (clade B) serpins in maintaining viability of both innate and adaptive immune cells.
Original languageEnglish
Pages (from-to)1 - 10
Number of pages10
JournalTissue Antigens
Issue number1
Publication statusPublished - 2008

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