The role of Rel/NF-κB transcription factors in B lymphocyte survival

Steve Gerondakis, Andreas Strasser

Research output: Contribution to journalReview ArticleResearchpeer-review

50 Citations (Scopus)

Abstract

Among the transcriptional mediators of the various signal transduction pathways that have been shown to regulate lymphocyte apoptosis, Rel/NF-κB transcription factors have emerged as key regulators of B cell survival during their differentiation and in their activation by antigens or mitogens. The aim of this review is to bring together recent findings on Rel/NF-κB regulation of B cell survival and to present an integrated model of how these transcription factors control apoptosis in a signal and differentiation-stage specific manner. In addition to providing a contemporary view of Rel/ NF-κB regulated B cell survival, the model described here is aimed to serve as a paradigm for how Rel/NF-κB family members control survival in different cell types during differentiation and in response to the plethora of signals that impinge on this master transcriptional regulatory pathway.

Original languageEnglish
Pages (from-to)159-166
Number of pages8
JournalSeminars in Immunology
Volume15
Issue number3
DOIs
Publication statusPublished - 1 Jan 2003
Externally publishedYes

Keywords

  • Apoptosis
  • B cells
  • Bcl-2
  • NF-κB

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