Abstract
Among the transcriptional mediators of the various signal transduction pathways that have been shown to regulate lymphocyte apoptosis, Rel/NF-κB transcription factors have emerged as key regulators of B cell survival during their differentiation and in their activation by antigens or mitogens. The aim of this review is to bring together recent findings on Rel/NF-κB regulation of B cell survival and to present an integrated model of how these transcription factors control apoptosis in a signal and differentiation-stage specific manner. In addition to providing a contemporary view of Rel/ NF-κB regulated B cell survival, the model described here is aimed to serve as a paradigm for how Rel/NF-κB family members control survival in different cell types during differentiation and in response to the plethora of signals that impinge on this master transcriptional regulatory pathway.
Original language | English |
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Pages (from-to) | 159-166 |
Number of pages | 8 |
Journal | Seminars in Immunology |
Volume | 15 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1 Jan 2003 |
Externally published | Yes |
Keywords
- Apoptosis
- B cells
- Bcl-2
- NF-κB