The role of proteases in regulating Eph/ephrin signaling

Lakmali S K Atapattu Mudiyanselage, Martin Lackmann, Peter W Janes

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41 Citations (Scopus)


Abstract Proteases regulate a myriad of cell functions, both in normal and disease states. In addition to protein turnover, they regulate a range of signalling processes, including those mediated by Eph receptors and their ephrin ligands. A variety of proteases is reported to directly cleave Ephs and/or ephrins under different conditions, to promote receptor and/or ligand shedding, and regulate receptor/ligand internalisation and signalling. They also cleave other adhesion proteins in response to Eph-ephrin interactions, to indirectly facilitate Eph-mediated functions. Proteases thus contribute to Eph/ephrin mediated changes in cell-cell and cell-matrix interactions, in cell morphology and in cell migration and invasion, in a manner which appears to be tightly regulated by, and co-ordinated with, Eph signalling. This review summarises the current literature describing the function and regulation of protease activities during Eph/ephrin-mediated cell signalling.
Original languageEnglish
Pages (from-to)294 - 307
Number of pages14
JournalCell Adhesion and Migration
Issue number4
Publication statusPublished - 2014

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