The role of placental homeobox genes in human fetal growth restriction

Padma Murthi, Gayathri Rajaraman, Shaun Patrick Brennecke, Bill Kalionis

Research output: Contribution to journalReview ArticleResearchpeer-review

8 Citations (Scopus)

Abstract

Fetal growth restriction (FGR) is an adverse pregnancy outcome associated with significant perinatal and paediatric morbidity and mortality, and an increased risk of chronic disease later in adult life. One of the key causes of adverse pregnancy outcome is fetal growth restriction (FGR). While a number of maternal, fetal, and environmental factors are known causes of FGR, the majority of FGR cases remain idiopathic. These idiopathic FGR pregnancies are frequently associated with placental insufficiency, possibly as a result of placental maldevelopment. Understanding the molecular mechanisms of abnormal placental development in idiopathic FGR is, therefore, of increasing importance. Here, we review our understanding of transcriptional control of normal placental development and abnormal placental development associated with human idiopathic FGR. We also assess the potential for understanding transcriptional control as a means for revealing new molecular targets for the detection, diagnosis, and clinical management of idiopathic FGR.

Original languageEnglish
Article number548171
Number of pages11
JournalJournal of Pregnancy
Volume2011
DOIs
Publication statusPublished - 2011

Cite this

@article{945773306157403aaa70680053ced814,
title = "The role of placental homeobox genes in human fetal growth restriction",
abstract = "Fetal growth restriction (FGR) is an adverse pregnancy outcome associated with significant perinatal and paediatric morbidity and mortality, and an increased risk of chronic disease later in adult life. One of the key causes of adverse pregnancy outcome is fetal growth restriction (FGR). While a number of maternal, fetal, and environmental factors are known causes of FGR, the majority of FGR cases remain idiopathic. These idiopathic FGR pregnancies are frequently associated with placental insufficiency, possibly as a result of placental maldevelopment. Understanding the molecular mechanisms of abnormal placental development in idiopathic FGR is, therefore, of increasing importance. Here, we review our understanding of transcriptional control of normal placental development and abnormal placental development associated with human idiopathic FGR. We also assess the potential for understanding transcriptional control as a means for revealing new molecular targets for the detection, diagnosis, and clinical management of idiopathic FGR.",
author = "Padma Murthi and Gayathri Rajaraman and Brennecke, {Shaun Patrick} and Bill Kalionis",
year = "2011",
doi = "10.1155/2011/548171",
language = "English",
volume = "2011",
journal = "Journal of Pregnancy",
issn = "2090-2727",
publisher = "Hindawi Publishing Corporation",

}

The role of placental homeobox genes in human fetal growth restriction. / Murthi, Padma; Rajaraman, Gayathri; Brennecke, Shaun Patrick; Kalionis, Bill.

In: Journal of Pregnancy, Vol. 2011, 548171, 2011.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - The role of placental homeobox genes in human fetal growth restriction

AU - Murthi, Padma

AU - Rajaraman, Gayathri

AU - Brennecke, Shaun Patrick

AU - Kalionis, Bill

PY - 2011

Y1 - 2011

N2 - Fetal growth restriction (FGR) is an adverse pregnancy outcome associated with significant perinatal and paediatric morbidity and mortality, and an increased risk of chronic disease later in adult life. One of the key causes of adverse pregnancy outcome is fetal growth restriction (FGR). While a number of maternal, fetal, and environmental factors are known causes of FGR, the majority of FGR cases remain idiopathic. These idiopathic FGR pregnancies are frequently associated with placental insufficiency, possibly as a result of placental maldevelopment. Understanding the molecular mechanisms of abnormal placental development in idiopathic FGR is, therefore, of increasing importance. Here, we review our understanding of transcriptional control of normal placental development and abnormal placental development associated with human idiopathic FGR. We also assess the potential for understanding transcriptional control as a means for revealing new molecular targets for the detection, diagnosis, and clinical management of idiopathic FGR.

AB - Fetal growth restriction (FGR) is an adverse pregnancy outcome associated with significant perinatal and paediatric morbidity and mortality, and an increased risk of chronic disease later in adult life. One of the key causes of adverse pregnancy outcome is fetal growth restriction (FGR). While a number of maternal, fetal, and environmental factors are known causes of FGR, the majority of FGR cases remain idiopathic. These idiopathic FGR pregnancies are frequently associated with placental insufficiency, possibly as a result of placental maldevelopment. Understanding the molecular mechanisms of abnormal placental development in idiopathic FGR is, therefore, of increasing importance. Here, we review our understanding of transcriptional control of normal placental development and abnormal placental development associated with human idiopathic FGR. We also assess the potential for understanding transcriptional control as a means for revealing new molecular targets for the detection, diagnosis, and clinical management of idiopathic FGR.

UR - http://www.scopus.com/inward/record.url?scp=84856011573&partnerID=8YFLogxK

U2 - 10.1155/2011/548171

DO - 10.1155/2011/548171

M3 - Review Article

C2 - 21547091

AN - SCOPUS:84856011573

VL - 2011

JO - Journal of Pregnancy

JF - Journal of Pregnancy

SN - 2090-2727

M1 - 548171

ER -