Abstract
The theory that many serious mental illnesses, in particular psychoses such as schizophrenia, may have a significant hormonal
aetiological component is fast gaining popularity and the support of scientific evidence. Oestrogen in particular has been
substantially investigated as a potential mediator of brain function in schizophrenia. Epidemiological and life-cycle data point
to significant differences in the incidence and course of schizophrenia between men and women suggests a protective role
of oestrogen. In vitro and in vivo preclinical research confirms oestradiol?s interactions with central neurotransmitter systems
implicated in the pathogenesis of schizophrenia, while results from randomised controlled trials investigating the antipsychotic
potential of oestrogen have been positive. Research into other neuroactive hormones with possible effects on mental state is a
rapidly evolving field that may hold new promise. Given that schizophrenia and related psychoses are pervasive and debilitating
conditions for which currently available treatments are often only partially effective and entail a high risk of serious side-effects,
novel therapeutic strategies are needed. The literature reviewed in this paper suggests that hormones such as oestrogen could be a
viable option, and it is hoped that with further research and larger trials, the oestrogen hypothesis can be translated into effective
clinical practice.
Original language | English |
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Pages (from-to) | 1 - 8 |
Number of pages | 8 |
Journal | Schizophrenia Research and Treatment |
Volume | 2012 |
DOIs | |
Publication status | Published - 2012 |