The role of natural products in targeting cardiovascular diseases via Nrf2 pathway: Novel molecular mechanisms and therapeutic approaches

Bee Kee Ooi, Kok Gan Chan, Bey Hing Goh, Wei Hsum Yap

    Research output: Contribution to journalReview ArticleOtherpeer-review

    24 Citations (Scopus)

    Abstract

    Cardiovascular diseases (CVDs) are closely linked to cellular oxidative stress and inflammation. This may be resulted from the imbalance generation of reactive oxygen species and its role in promoting inflammation, thereby contributing to endothelial dysfunction and cardiovascular complications. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that plays a significant role in regulating expression of antioxidant and cytoprotective enzymes in response to oxidative stress. Natural products have emerged as a potential source of bioactive compounds which have shown to protect against atherogenesis development by activating Nrf2 signaling. This review aims to provide a comprehensive summary of the published data on the function, regulation and activation of Nrf2 as well as the molecular mechanisms of natural products in regulating Nrf2 signaling. The beneficial effects of using natural bioactive compounds as apromising therapeutic approach for the prevention and treatment of CVDs are reviewed.

    Original languageEnglish
    Article number1308
    Number of pages18
    JournalFrontiers in Pharmacology
    Volume9
    DOIs
    Publication statusPublished - 15 Nov 2018

    Keywords

    • Cardiovascular diseases (cvds)
    • Natural products
    • Nuclear factor erythroid 2-related factor 2 (nrf2)
    • Nuclear factor-b (nf-b)
    • Oxidative stress

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