The role of natural killer cells in hepatitis C infection

Jessica A Howell, Kumar Visvanathan

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4 Citations (Scopus)


HCV infection is an exponentially growing health burden worldwide, with an estimated 170 million people infected. Although therapies for HCV are continually improving, there remain a considerable proportion of patients who do not achieve viral eradication and develop liver disease. Natural killer (NK) cells are crucial for T-cell activation and are one of the first-line sentinel cell responders to viral infection. A recent explosion in studies exploring the role of NK cells in HCV infection has yielded important mechanistic information and intriguing potential therapeutic options for HCV infection. This review provides a general overview of normal NK cell function and outlines some of the important mechanisms characterizing the immune interplay between NK cells and HCV infection.
Original languageEnglish
Pages (from-to)853 - 865
Number of pages13
JournalAntiviral Therapy
Issue number7
Publication statusPublished - 2013

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