The role of naive T-cells in HIV-1 pathogenesis: An emerging key player.

Gabriela Khoury, Reena Rajasuriar, Sharon Lewin, Paul Cameron

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Abstract

Here we review the basic homeostatic mechanisms that maintain naive CD4+ T-cells and discuss recent developments in understanding the impact of HIV infection on naive CD4+ T-cells. Finally we review therapeutic interventions in HIV-infected individuals aimed at specifically enhancing recovery of naive CD4+ T-cells.
Original languageEnglish
Pages (from-to)253 - 267
Number of pages15
JournalClinical Immunology
Volume141
Issue number3
Publication statusPublished - 2011

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