The Role of Mitochondrial DNA in Tumorigenesis

Vanessa K Y Yeung; Adam Dickinson; Justin Charles St John

doi:10.1007/978-1-62703-101-1_6

The Role of Mitochondrial DNA in Tumorigenesis

Vanessa K Y Yeung, Adam Dickinson, Justin Charles St John

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review

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Abstract

Mitochondria are widely accepted as an important organelle responsible for numerous processes ranging from ATP production, fatty acid oxidation, as well as the control of cellular apoptosis and steroidogenesis. The mitochondrial genome (mtDNA) exists exclusively within the mitochondrion and in multiple copies within the mitochondrial matrix. In tumorigenesis, modifications are known to arise during the transcription and replication of mtDNA, which often lead to changes in mtDNA copy number. Moreover, different cancers tend to be associated with base changes at various locations within the mitochondrial genome. This chapter discusses current knowledge of the relationship between mtDNA and cancer. The influence of various tumors on mtDNA copy number, and key mtDNA variants associated with disease and cancer will also be discussed, together with the role of mitochondria in tumor cell energy metabolism.

Original language	English
Title of host publication	Mitochondrial DNA, Mitochondria, Disease and Stem Cells
Editors	Justin Charles St John
Place of Publication	United States
Publisher	Humana Press
Pages	119-155
Number of pages	37
ISBN (Electronic)	9781627031011
ISBN (Print)	9781627031004
DOIs	https://doi.org/10.1007/978-1-62703-101-1_6
Publication status	Published - 1 Jan 2013

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10.1007/978-1-62703-101-1_6

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abstract = "Mitochondria are widely accepted as an important organelle responsible for numerous processes ranging from ATP production, fatty acid oxidation, as well as the control of cellular apoptosis and steroidogenesis. The mitochondrial genome (mtDNA) exists exclusively within the mitochondrion and in multiple copies within the mitochondrial matrix. In tumorigenesis, modifications are known to arise during the transcription and replication of mtDNA, which often lead to changes in mtDNA copy number. Moreover, different cancers tend to be associated with base changes at various locations within the mitochondrial genome. This chapter discusses current knowledge of the relationship between mtDNA and cancer. The influence of various tumors on mtDNA copy number, and key mtDNA variants associated with disease and cancer will also be discussed, together with the role of mitochondria in tumor cell energy metabolism.",

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AU - Dickinson, Adam

AU - St John, Justin Charles

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N2 - Mitochondria are widely accepted as an important organelle responsible for numerous processes ranging from ATP production, fatty acid oxidation, as well as the control of cellular apoptosis and steroidogenesis. The mitochondrial genome (mtDNA) exists exclusively within the mitochondrion and in multiple copies within the mitochondrial matrix. In tumorigenesis, modifications are known to arise during the transcription and replication of mtDNA, which often lead to changes in mtDNA copy number. Moreover, different cancers tend to be associated with base changes at various locations within the mitochondrial genome. This chapter discusses current knowledge of the relationship between mtDNA and cancer. The influence of various tumors on mtDNA copy number, and key mtDNA variants associated with disease and cancer will also be discussed, together with the role of mitochondria in tumor cell energy metabolism.

AB - Mitochondria are widely accepted as an important organelle responsible for numerous processes ranging from ATP production, fatty acid oxidation, as well as the control of cellular apoptosis and steroidogenesis. The mitochondrial genome (mtDNA) exists exclusively within the mitochondrion and in multiple copies within the mitochondrial matrix. In tumorigenesis, modifications are known to arise during the transcription and replication of mtDNA, which often lead to changes in mtDNA copy number. Moreover, different cancers tend to be associated with base changes at various locations within the mitochondrial genome. This chapter discusses current knowledge of the relationship between mtDNA and cancer. The influence of various tumors on mtDNA copy number, and key mtDNA variants associated with disease and cancer will also be discussed, together with the role of mitochondria in tumor cell energy metabolism.

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BT - Mitochondrial DNA, Mitochondria, Disease and Stem Cells

A2 - St John, Justin Charles

PB - Humana Press

CY - United States

ER -

The Role of Mitochondrial DNA in Tumorigenesis

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The Role of Mitochondrial DNA in Tumorigenesis

Abstract

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Biology of EGFR mutation in glioblastoma multiforme

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