The role of mitochondrial DNA copy number, variants, and haplotypes in farm animal developmental outcome

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Abstract

The vast majority of cellular energy is generated through the process of oxidative phosphorylation, which takes place in the electron transport chain in the mitochondria. The electron transport chain is encoded by 2 genomes, the chromosomal and the mitochondrial genomes. Mitochondrial DNA is associated with a number of traits, which include tolerance to heat, growth and physical performance, meat and milk quality, and fertility. Mitochondrial genomes can be clustered into groups known as mtDNA haplotypes. Mitochondrial DNA haplotypes are a potential genetic source for manipulating phenotypes in farm animals. The use of assisted reproductive technologies, such as nuclear transfer, allows favorable chromosomal genetic traits to be mixed and matched with sought after mtDNA haplotype traits. As a result super breeds can be generated.

Original languageEnglish
Pages (from-to)S133-S146
Number of pages14
JournalDomestic Animal Endocrinology
Volume56
DOIs
Publication statusPublished - Jul 2016
Event8th International Congress on Farm Animal Endocrinology - Hotel Legoland, Billund, Denmark
Duration: 27 Aug 201529 Aug 2015
http://anis.au.dk/en/icfae-2015/

Keywords

  • Development
  • Genetic diversity
  • Haplotype
  • Mitochondrial DNA
  • Somatic cell nuclear transfer

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