The Role of Metabolomics in Antiparasitic Drug Discovery

Carlo R. Giannangelo, Katherine M. Ellis, Anna E. Sexton, Daniel Stoessel, Darren J. Creek

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Abstract

Metabolomics involves the global measurement of small molecule metabolites in a biological system and allows the comprehensive investigation of metabolic pathways in pathogenic parasites. Metabolomics studies have enabled the discovery of novel aspects of parasite metabolism that constitute attractive drug targets, and have elucidated metabolic targets of antiparasitic compounds. This chapter provides an introduction to parasite metabolomics and describes metabolomics methods suitable for kinetoplastid and apicomplexan parasites. Several examples are provided describing applications of metabolomics to understand the mechanisms of action and resistance for a range of antiprotozoal compounds. This unbiased elucidation of drug mechanisms with metabolomics will facilitate the discovery and development of new drugs for parasitic diseases of global importance.

Original languageEnglish
Title of host publicationComprehensive Analysis of Parasite Biology
Subtitle of host publicationFrom Metabolism to Drug Discovery
EditorsSylke Müller, Rachel Cerdan, Ovidiu Radulescu
Place of PublicationWeinheim Germany
PublisherWiley-VCH Verlag GmbH & Co. KGaA
Pages321-342
Number of pages22
ISBN (Electronic)9783527694082, 9783527694099, 9783527694112, 9783527694105
ISBN (Print)9783527339044
DOIs
Publication statusPublished - 5 Aug 2016

Publication series

NameDrug Discovery in Infectious Diseases
PublisherWiley-VCH Verlag GmbH & Co. KGaA

Keywords

  • Antiparasitic drug discovery
  • Antiprotozoal compounds
  • Apicomplexan parasites
  • Kinetoplastid parasite
  • Metabolomics
  • Pathogenic parasites

Cite this

Giannangelo, C. R., Ellis, K. M., Sexton, A. E., Stoessel, D., & Creek, D. J. (2016). The Role of Metabolomics in Antiparasitic Drug Discovery. In S. Müller, R. Cerdan, & O. Radulescu (Eds.), Comprehensive Analysis of Parasite Biology: From Metabolism to Drug Discovery (pp. 321-342). (Drug Discovery in Infectious Diseases). Weinheim Germany: Wiley-VCH Verlag GmbH & Co. KGaA. https://doi.org/10.1002/9783527694082.ch14
Giannangelo, Carlo R. ; Ellis, Katherine M. ; Sexton, Anna E. ; Stoessel, Daniel ; Creek, Darren J. / The Role of Metabolomics in Antiparasitic Drug Discovery. Comprehensive Analysis of Parasite Biology: From Metabolism to Drug Discovery. editor / Sylke Müller ; Rachel Cerdan ; Ovidiu Radulescu. Weinheim Germany : Wiley-VCH Verlag GmbH & Co. KGaA, 2016. pp. 321-342 (Drug Discovery in Infectious Diseases).
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Giannangelo, CR, Ellis, KM, Sexton, AE, Stoessel, D & Creek, DJ 2016, The Role of Metabolomics in Antiparasitic Drug Discovery. in S Müller, R Cerdan & O Radulescu (eds), Comprehensive Analysis of Parasite Biology: From Metabolism to Drug Discovery. Drug Discovery in Infectious Diseases, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Germany, pp. 321-342. https://doi.org/10.1002/9783527694082.ch14

The Role of Metabolomics in Antiparasitic Drug Discovery. / Giannangelo, Carlo R.; Ellis, Katherine M.; Sexton, Anna E.; Stoessel, Daniel; Creek, Darren J.

Comprehensive Analysis of Parasite Biology: From Metabolism to Drug Discovery. ed. / Sylke Müller; Rachel Cerdan; Ovidiu Radulescu. Weinheim Germany : Wiley-VCH Verlag GmbH & Co. KGaA, 2016. p. 321-342 (Drug Discovery in Infectious Diseases).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

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Giannangelo CR, Ellis KM, Sexton AE, Stoessel D, Creek DJ. The Role of Metabolomics in Antiparasitic Drug Discovery. In Müller S, Cerdan R, Radulescu O, editors, Comprehensive Analysis of Parasite Biology: From Metabolism to Drug Discovery. Weinheim Germany: Wiley-VCH Verlag GmbH & Co. KGaA. 2016. p. 321-342. (Drug Discovery in Infectious Diseases). https://doi.org/10.1002/9783527694082.ch14