The Role of Mesenchymal Stem Cells in the Functions and Pathologies of the Human Placenta

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Abstract

The proper function of the human placenta is essential for all stages of pregnancy and for the successful outcome of a healthy baby. Nurturing the fetus and removing fetal waste products require the placenta to carry out a wide range of functions. The increasing demands on the placenta to support the rapidly growing fetal placenta are met by establishing and maintaining an interface with the mother’s uterus and under- lying tissues, and by modifying vessels in the maternal circulation to increase blood flow to the placenta. Given the complex morphological and physiological changes that occur in the placenta during its formation, and the varied functions that the placenta performs, it is not surprising that disruption of these processes results in significant placental pathologies. Clinically, the most important of these pathologies is the hyper- tensive disorder preeclampsia (PE). Despite the placenta’s complex and critical roles, there are major gaps in our understanding of the biology and molecular mechanisms involved in normal and pathological placental development. Here, we highlight recent studies providing evidence for stem cells as important new players in the formation of the placenta, the establishment of the fetal-maternal interface, and the pathology of PE.
Original languageEnglish
Title of host publicationPlacenta: The Tree of Life
EditorsOrnella Parolini
PublisherCRC Press
Pages13-38
Number of pages26
ISBN (Print)9781498700269
Publication statusPublished - 17 Feb 2016

Publication series

NameGene and Cell Therapy Series
PublisherCRC Press Taylor and Francis Group

Cite this

Kusuma, G. D., Murthi, P., & Kalionis, B. (2016). The Role of Mesenchymal Stem Cells in the Functions and Pathologies of the Human Placenta. In O. Parolini (Ed.), Placenta: The Tree of Life (pp. 13-38). (Gene and Cell Therapy Series). CRC Press.
Kusuma, Gina Diamanta ; Murthi, Padma ; Kalionis, Bill. / The Role of Mesenchymal Stem Cells in the Functions and Pathologies of the Human Placenta. Placenta: The Tree of Life. editor / Ornella Parolini. CRC Press, 2016. pp. 13-38 (Gene and Cell Therapy Series).
@inbook{aa7d67a156bc4a5da35c9240055e4052,
title = "The Role of Mesenchymal Stem Cells in the Functions and Pathologies of the Human Placenta",
abstract = "The proper function of the human placenta is essential for all stages of pregnancy and for the successful outcome of a healthy baby. Nurturing the fetus and removing fetal waste products require the placenta to carry out a wide range of functions. The increasing demands on the placenta to support the rapidly growing fetal placenta are met by establishing and maintaining an interface with the mother’s uterus and under- lying tissues, and by modifying vessels in the maternal circulation to increase blood flow to the placenta. Given the complex morphological and physiological changes that occur in the placenta during its formation, and the varied functions that the placenta performs, it is not surprising that disruption of these processes results in significant placental pathologies. Clinically, the most important of these pathologies is the hyper- tensive disorder preeclampsia (PE). Despite the placenta’s complex and critical roles, there are major gaps in our understanding of the biology and molecular mechanisms involved in normal and pathological placental development. Here, we highlight recent studies providing evidence for stem cells as important new players in the formation of the placenta, the establishment of the fetal-maternal interface, and the pathology of PE.",
author = "Kusuma, {Gina Diamanta} and Padma Murthi and Bill Kalionis",
year = "2016",
month = "2",
day = "17",
language = "English",
isbn = "9781498700269",
series = "Gene and Cell Therapy Series",
publisher = "CRC Press",
pages = "13--38",
editor = "Parolini, {Ornella }",
booktitle = "Placenta: The Tree of Life",
address = "Australia",

}

Kusuma, GD, Murthi, P & Kalionis, B 2016, The Role of Mesenchymal Stem Cells in the Functions and Pathologies of the Human Placenta. in O Parolini (ed.), Placenta: The Tree of Life. Gene and Cell Therapy Series, CRC Press, pp. 13-38.

The Role of Mesenchymal Stem Cells in the Functions and Pathologies of the Human Placenta. / Kusuma, Gina Diamanta; Murthi, Padma; Kalionis, Bill.

Placenta: The Tree of Life. ed. / Ornella Parolini. CRC Press, 2016. p. 13-38 (Gene and Cell Therapy Series).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

TY - CHAP

T1 - The Role of Mesenchymal Stem Cells in the Functions and Pathologies of the Human Placenta

AU - Kusuma, Gina Diamanta

AU - Murthi, Padma

AU - Kalionis, Bill

PY - 2016/2/17

Y1 - 2016/2/17

N2 - The proper function of the human placenta is essential for all stages of pregnancy and for the successful outcome of a healthy baby. Nurturing the fetus and removing fetal waste products require the placenta to carry out a wide range of functions. The increasing demands on the placenta to support the rapidly growing fetal placenta are met by establishing and maintaining an interface with the mother’s uterus and under- lying tissues, and by modifying vessels in the maternal circulation to increase blood flow to the placenta. Given the complex morphological and physiological changes that occur in the placenta during its formation, and the varied functions that the placenta performs, it is not surprising that disruption of these processes results in significant placental pathologies. Clinically, the most important of these pathologies is the hyper- tensive disorder preeclampsia (PE). Despite the placenta’s complex and critical roles, there are major gaps in our understanding of the biology and molecular mechanisms involved in normal and pathological placental development. Here, we highlight recent studies providing evidence for stem cells as important new players in the formation of the placenta, the establishment of the fetal-maternal interface, and the pathology of PE.

AB - The proper function of the human placenta is essential for all stages of pregnancy and for the successful outcome of a healthy baby. Nurturing the fetus and removing fetal waste products require the placenta to carry out a wide range of functions. The increasing demands on the placenta to support the rapidly growing fetal placenta are met by establishing and maintaining an interface with the mother’s uterus and under- lying tissues, and by modifying vessels in the maternal circulation to increase blood flow to the placenta. Given the complex morphological and physiological changes that occur in the placenta during its formation, and the varied functions that the placenta performs, it is not surprising that disruption of these processes results in significant placental pathologies. Clinically, the most important of these pathologies is the hyper- tensive disorder preeclampsia (PE). Despite the placenta’s complex and critical roles, there are major gaps in our understanding of the biology and molecular mechanisms involved in normal and pathological placental development. Here, we highlight recent studies providing evidence for stem cells as important new players in the formation of the placenta, the establishment of the fetal-maternal interface, and the pathology of PE.

M3 - Chapter (Book)

SN - 9781498700269

T3 - Gene and Cell Therapy Series

SP - 13

EP - 38

BT - Placenta: The Tree of Life

A2 - Parolini, Ornella

PB - CRC Press

ER -

Kusuma GD, Murthi P, Kalionis B. The Role of Mesenchymal Stem Cells in the Functions and Pathologies of the Human Placenta. In Parolini O, editor, Placenta: The Tree of Life. CRC Press. 2016. p. 13-38. (Gene and Cell Therapy Series).