The Role of Maternally Acquired Antibody in Providing Protective Immunity Against Nontyphoidal Salmonella in Urban Vietnamese Infants: A Birth Cohort Study

Ruklanthi De Alwis, Le Thi Phuong Tu, Nhi Le Thi Quynh, Corinne N. Thompson, Katherine L. Anders, Nguyen Thi Van Thuy, Nguyen Trong Hieu, Lu Lan Vi, Nguyen Van Vinh Chau, Vu Thuy Duong, Tran Thi Hong Chau, Ha Thanh Tuyen, Tran Vu Thieu Nga, Pham Van Minh, Trinh Van Tan, Trang Nguyen Hoang Thu, Tran Do Hoang Nhu, Guy E. Thwaites, Cameron Simmons, Stephen Baker

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background Nontyphoidal Salmonella (NTS) organisms are a major cause of gastroenteritis and bacteremia, but little is known about maternally acquired immunity and natural exposure in infant populations residing in areas where NTS disease is highly endemic. Methods We recruited 503 pregnant mothers and their infants (following delivery) from urban areas in Vietnam and followed infants until they were 1 year old. Exposure to the dominant NTS serovars, Salmonella enterica serovars Typhimurium and Enteritidis, were assessed using lipopolysaccharide (LPS) O antigen-specific antibodies. Antibody dynamics, the role of maternally acquired antibodies, and NTS seroincidence rates were modeled using multivariate linear risk factor models and generalized additive mixed-effect models. Results Transplacental transfer of NTS LPS-specific maternal antibodies to infants was highly efficient. Waning of transplacentally acquired NTS LPS-specific antibodies at 4 months of age left infants susceptible to Salmonella organisms, after which they began to seroconvert. High seroincidences of S. Typhimurium and S. Enteritidis LPS were observed, and infants born with higher anti-LPS titers had greater plasma bactericidal activity and longer protection from seroconversion. Conclusions Although Vietnamese infants have extensive exposure to NTS, maternally acquired antibodies appear to play a protective role against NTS infections during early infancy. These findings suggest that prenatal immunization may be an appropriate strategy to protect vulnerable infants from NTS disease.

Original languageEnglish
Pages (from-to)295-304
Number of pages10
JournalJournal of Infectious Diseases
Volume219
Issue number2
DOIs
Publication statusPublished - 7 Jan 2019

Keywords

  • infant antibodies
  • maternal antibodies
  • maternal immunization
  • Nontyphoidal Salmonella
  • NTS
  • Salmonella Enteritidis
  • Salmonella Typhimurium
  • seroepidemiology
  • seroincidence
  • transplacentally acquired immunity
  • Vietnam

Cite this

De Alwis, Ruklanthi ; Tu, Le Thi Phuong ; Quynh, Nhi Le Thi ; Thompson, Corinne N. ; Anders, Katherine L. ; Van Thuy, Nguyen Thi ; Hieu, Nguyen Trong ; Vi, Lu Lan ; Chau, Nguyen Van Vinh ; Duong, Vu Thuy ; Chau, Tran Thi Hong ; Tuyen, Ha Thanh ; Nga, Tran Vu Thieu ; Minh, Pham Van ; Tan, Trinh Van ; Thu, Trang Nguyen Hoang ; Nhu, Tran Do Hoang ; Thwaites, Guy E. ; Simmons, Cameron ; Baker, Stephen. / The Role of Maternally Acquired Antibody in Providing Protective Immunity Against Nontyphoidal Salmonella in Urban Vietnamese Infants : A Birth Cohort Study. In: Journal of Infectious Diseases. 2019 ; Vol. 219, No. 2. pp. 295-304.
@article{4eca065a0bb046e49d2dea8ff4287c72,
title = "The Role of Maternally Acquired Antibody in Providing Protective Immunity Against Nontyphoidal Salmonella in Urban Vietnamese Infants: A Birth Cohort Study",
abstract = "Background Nontyphoidal Salmonella (NTS) organisms are a major cause of gastroenteritis and bacteremia, but little is known about maternally acquired immunity and natural exposure in infant populations residing in areas where NTS disease is highly endemic. Methods We recruited 503 pregnant mothers and their infants (following delivery) from urban areas in Vietnam and followed infants until they were 1 year old. Exposure to the dominant NTS serovars, Salmonella enterica serovars Typhimurium and Enteritidis, were assessed using lipopolysaccharide (LPS) O antigen-specific antibodies. Antibody dynamics, the role of maternally acquired antibodies, and NTS seroincidence rates were modeled using multivariate linear risk factor models and generalized additive mixed-effect models. Results Transplacental transfer of NTS LPS-specific maternal antibodies to infants was highly efficient. Waning of transplacentally acquired NTS LPS-specific antibodies at 4 months of age left infants susceptible to Salmonella organisms, after which they began to seroconvert. High seroincidences of S. Typhimurium and S. Enteritidis LPS were observed, and infants born with higher anti-LPS titers had greater plasma bactericidal activity and longer protection from seroconversion. Conclusions Although Vietnamese infants have extensive exposure to NTS, maternally acquired antibodies appear to play a protective role against NTS infections during early infancy. These findings suggest that prenatal immunization may be an appropriate strategy to protect vulnerable infants from NTS disease.",
keywords = "infant antibodies, maternal antibodies, maternal immunization, Nontyphoidal Salmonella, NTS, Salmonella Enteritidis, Salmonella Typhimurium, seroepidemiology, seroincidence, transplacentally acquired immunity, Vietnam",
author = "{De Alwis}, Ruklanthi and Tu, {Le Thi Phuong} and Quynh, {Nhi Le Thi} and Thompson, {Corinne N.} and Anders, {Katherine L.} and {Van Thuy}, {Nguyen Thi} and Hieu, {Nguyen Trong} and Vi, {Lu Lan} and Chau, {Nguyen Van Vinh} and Duong, {Vu Thuy} and Chau, {Tran Thi Hong} and Tuyen, {Ha Thanh} and Nga, {Tran Vu Thieu} and Minh, {Pham Van} and Tan, {Trinh Van} and Thu, {Trang Nguyen Hoang} and Nhu, {Tran Do Hoang} and Thwaites, {Guy E.} and Cameron Simmons and Stephen Baker",
year = "2019",
month = "1",
day = "7",
doi = "10.1093/infdis/jiy501",
language = "English",
volume = "219",
pages = "295--304",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "2",

}

De Alwis, R, Tu, LTP, Quynh, NLT, Thompson, CN, Anders, KL, Van Thuy, NT, Hieu, NT, Vi, LL, Chau, NVV, Duong, VT, Chau, TTH, Tuyen, HT, Nga, TVT, Minh, PV, Tan, TV, Thu, TNH, Nhu, TDH, Thwaites, GE, Simmons, C & Baker, S 2019, 'The Role of Maternally Acquired Antibody in Providing Protective Immunity Against Nontyphoidal Salmonella in Urban Vietnamese Infants: A Birth Cohort Study' Journal of Infectious Diseases, vol. 219, no. 2, pp. 295-304. https://doi.org/10.1093/infdis/jiy501

The Role of Maternally Acquired Antibody in Providing Protective Immunity Against Nontyphoidal Salmonella in Urban Vietnamese Infants : A Birth Cohort Study. / De Alwis, Ruklanthi; Tu, Le Thi Phuong; Quynh, Nhi Le Thi; Thompson, Corinne N.; Anders, Katherine L.; Van Thuy, Nguyen Thi; Hieu, Nguyen Trong; Vi, Lu Lan; Chau, Nguyen Van Vinh; Duong, Vu Thuy; Chau, Tran Thi Hong; Tuyen, Ha Thanh; Nga, Tran Vu Thieu; Minh, Pham Van; Tan, Trinh Van; Thu, Trang Nguyen Hoang; Nhu, Tran Do Hoang; Thwaites, Guy E.; Simmons, Cameron; Baker, Stephen.

In: Journal of Infectious Diseases, Vol. 219, No. 2, 07.01.2019, p. 295-304.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - The Role of Maternally Acquired Antibody in Providing Protective Immunity Against Nontyphoidal Salmonella in Urban Vietnamese Infants

T2 - A Birth Cohort Study

AU - De Alwis, Ruklanthi

AU - Tu, Le Thi Phuong

AU - Quynh, Nhi Le Thi

AU - Thompson, Corinne N.

AU - Anders, Katherine L.

AU - Van Thuy, Nguyen Thi

AU - Hieu, Nguyen Trong

AU - Vi, Lu Lan

AU - Chau, Nguyen Van Vinh

AU - Duong, Vu Thuy

AU - Chau, Tran Thi Hong

AU - Tuyen, Ha Thanh

AU - Nga, Tran Vu Thieu

AU - Minh, Pham Van

AU - Tan, Trinh Van

AU - Thu, Trang Nguyen Hoang

AU - Nhu, Tran Do Hoang

AU - Thwaites, Guy E.

AU - Simmons, Cameron

AU - Baker, Stephen

PY - 2019/1/7

Y1 - 2019/1/7

N2 - Background Nontyphoidal Salmonella (NTS) organisms are a major cause of gastroenteritis and bacteremia, but little is known about maternally acquired immunity and natural exposure in infant populations residing in areas where NTS disease is highly endemic. Methods We recruited 503 pregnant mothers and their infants (following delivery) from urban areas in Vietnam and followed infants until they were 1 year old. Exposure to the dominant NTS serovars, Salmonella enterica serovars Typhimurium and Enteritidis, were assessed using lipopolysaccharide (LPS) O antigen-specific antibodies. Antibody dynamics, the role of maternally acquired antibodies, and NTS seroincidence rates were modeled using multivariate linear risk factor models and generalized additive mixed-effect models. Results Transplacental transfer of NTS LPS-specific maternal antibodies to infants was highly efficient. Waning of transplacentally acquired NTS LPS-specific antibodies at 4 months of age left infants susceptible to Salmonella organisms, after which they began to seroconvert. High seroincidences of S. Typhimurium and S. Enteritidis LPS were observed, and infants born with higher anti-LPS titers had greater plasma bactericidal activity and longer protection from seroconversion. Conclusions Although Vietnamese infants have extensive exposure to NTS, maternally acquired antibodies appear to play a protective role against NTS infections during early infancy. These findings suggest that prenatal immunization may be an appropriate strategy to protect vulnerable infants from NTS disease.

AB - Background Nontyphoidal Salmonella (NTS) organisms are a major cause of gastroenteritis and bacteremia, but little is known about maternally acquired immunity and natural exposure in infant populations residing in areas where NTS disease is highly endemic. Methods We recruited 503 pregnant mothers and their infants (following delivery) from urban areas in Vietnam and followed infants until they were 1 year old. Exposure to the dominant NTS serovars, Salmonella enterica serovars Typhimurium and Enteritidis, were assessed using lipopolysaccharide (LPS) O antigen-specific antibodies. Antibody dynamics, the role of maternally acquired antibodies, and NTS seroincidence rates were modeled using multivariate linear risk factor models and generalized additive mixed-effect models. Results Transplacental transfer of NTS LPS-specific maternal antibodies to infants was highly efficient. Waning of transplacentally acquired NTS LPS-specific antibodies at 4 months of age left infants susceptible to Salmonella organisms, after which they began to seroconvert. High seroincidences of S. Typhimurium and S. Enteritidis LPS were observed, and infants born with higher anti-LPS titers had greater plasma bactericidal activity and longer protection from seroconversion. Conclusions Although Vietnamese infants have extensive exposure to NTS, maternally acquired antibodies appear to play a protective role against NTS infections during early infancy. These findings suggest that prenatal immunization may be an appropriate strategy to protect vulnerable infants from NTS disease.

KW - infant antibodies

KW - maternal antibodies

KW - maternal immunization

KW - Nontyphoidal Salmonella

KW - NTS

KW - Salmonella Enteritidis

KW - Salmonella Typhimurium

KW - seroepidemiology

KW - seroincidence

KW - transplacentally acquired immunity

KW - Vietnam

UR - http://www.scopus.com/inward/record.url?scp=85059224832&partnerID=8YFLogxK

U2 - 10.1093/infdis/jiy501

DO - 10.1093/infdis/jiy501

M3 - Article

VL - 219

SP - 295

EP - 304

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 2

ER -