The role of lnk (Sh2b3) in the regulation of jak-stat signalling in haematopoiesis

Rhiannon Morris, Liesl Butler, Andrew Perkins, Nadia J. Kershaw, Jeffrey J. Babon

Research output: Contribution to journalReview ArticleResearchpeer-review

3 Citations (Scopus)

Abstract

LNK is a member of the SH2B family of adaptor proteins and is a non-redundant regulator of cytokine signalling. Cytokines are secreted intercellular messengers that bind to specific receptors on the surface of target cells to activate the Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) signalling pathway. Activation of the JAK-STAT pathway leads to proliferative and often inflammatory effects, and so the amplitude and duration of signalling are tightly controlled. LNK binds phosphotyrosine residues to signalling proteins downstream of cytokines and constrains JAK-STAT signalling. Mutations in LNK have been identified in a range of haematological and inflammatory diseases due to increased signalling following the loss of LNK function. Here, we review the regulation of JAK-STAT signalling via the adaptor protein LNK and discuss the role of LNK in haematological diseases.

Original languageEnglish
Article number24
Number of pages10
JournalPharmaceuticals
Volume15
Issue number1
DOIs
Publication statusPublished - Jan 2022

Keywords

  • JAK-STAT
  • Myeloproliferative neoplasms
  • SH2B3

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